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MedKoo Cat#: 412418 | Name: Tenilsetam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tenilsetam is a cognition-enhancing drug successfully used for the treatment of patients suffering from Alzheimer's disease. According to the mechanism proposed, it inhibits of advanced glycation end-product (AGE) formation.

Chemical Structure

Tenilsetam
Tenilsetam
CAS#86696-86-8

Theoretical Analysis

MedKoo Cat#: 412418

Name: Tenilsetam

CAS#: 86696-86-8

Chemical Formula: C8H10N2OS

Exact Mass: 182.0514

Molecular Weight: 182.24

Elemental Analysis: C, 52.73; H, 5.53; N, 15.37; O, 8.78; S, 17.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tenilsetam; CAS997; CAS-997; CAS 997
IUPAC/Chemical Name
3-(thiophen-2-yl)piperazin-2-one
InChi Key
BBACKDMGYMXYLE-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H10N2OS/c11-8-7(9-3-4-10-8)6-2-1-5-12-6/h1-2,5,7,9H,3-4H2,(H,10,11)
SMILES Code
O=C1NCCNC1c2sccc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gyengesi E, Liang H, Millington C, Sonego S, Sirijovski D, Gunawardena D, Dhananjayan K, Venigalla M, Niedermayer G, Münch G. Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. Pharm Res. 2018 Jan 5;35(1):22. doi: 10.1007/s11095-017-2326-9. PMID: 29305671. 2: Hoffmann J, Alt A, Lin J, Lochnit G, Schubert U, Schleicher E, Chavakis T, Brownlee M, Van der Woude FJ, Preissner KT, Hammes HP. Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss. Thromb Haemost. 2006 Apr;95(4):689-95. PMID: 16601840. 3: Shoda H, Miyata S, Liu BF, Yamada H, Ohara T, Suzuki K, Oimomi M, Kasuga M. Inhibitory effects of tenilsetam on the Maillard reaction. Endocrinology. 1997 May;138(5):1886-92. doi: 10.1210/endo.138.5.5151. PMID: 9112383. 4: Webster J, Urban C, Berbaum K, Loske C, Alpar A, Gärtner U, de Arriba SG, Arendt T, Münch G. The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal. Neurotox Res. 2005;7(1-2):95-101. doi: 10.1007/BF03033780. PMID: 15639802. 5: Münch G, Taneli Y, Schraven E, Schindler U, Schinzel R, Palm D, Riederer P. The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. J Neural Transm Park Dis Dement Sect. 1994;8(3):193-208. doi: 10.1007/BF02260940. PMID: 7748463. 6: Saletu B, Semlitsch HV, Anderer P, Resch F, Presslich O, Schuster P. Psychophysiological research in psychiatry and neuropsychopharmacology. II. The investigation of antihypoxidotic/nootropic drugs (tenilsetam and co-dergocrine- mesylate) in elderlies with the Viennese Psychophysiological Test-System (VPTS). Methods Find Exp Clin Pharmacol. 1989 Jan;11(1):43-55. PMID: 2716439. 7: Dukic-Stefanovic S, Schinzel R, Riederer P, Münch G. AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? Biogerontology. 2001;2(1):19-34. doi: 10.1023/a:1010052800347. PMID: 11708614. 8: Nenna A, Nappi F, Avtaar Singh SS, Sutherland FW, Di Domenico F, Chello M, Spadaccio C. Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease. Res Cardiovasc Med. 2015 May 23;4(2):e26949. doi: 10.5812/cardiovascmed.4(2)2015.26949. PMID: 26393232; PMCID: PMC4571620. 9: Jakus V. Uloha neenzýmovej glykácie a glykooxidácie v rozvoji diabetických vaskulárnych komplikácií [The role of nonenzymatic glycation and glyco-oxidation in the development of diabetic vascular complications]. Cesk Fysiol. 2003 May;52(2):51-65. Slovak. PMID: 12827898. 10: Sztanke K, Pasternak K. The Maillard reaction inhibitors and their biological and therapeutic significance. Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):156-8. PMID: 15323184.