Motolimod, also known as VTX-2337, is a small-molecule Toll-like receptor 8 (TLR8) agonist with potential immunostimulating and antineoplastic activities. TLR8 agonist VTX-2337 binds to TLR8, present in cutaneous dendritic cells, monocytes/macrophages, and mast cells, which may result in the activation of the central transcription factor nuclear factor-B, the secretion of proinflammatory cytokines and other mediators, and a Th1-weighted antitumoral cellular immune response. Primarily localized to endosomal membranes intracellularly, TLR8, like other TLRs, recognizes pathogen-associated molecular patterns (PAMPs) and plays a key role in the innate immune system.
MedKoo Cat#: 203153
Name: Motolimod
CAS#: 926927-61-9
Chemical Formula: C28H34N4O2
Exact Mass: 458.2682
Molecular Weight: 458.61
Elemental Analysis: C, 73.33; H, 7.47; N, 12.22; O, 6.98
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.0 | 56.69 | |
| DMSO:PBS (pH 7.2) (1:4) | 0.2 | 0.44 | |
| Ethanol | 15.0 | 32.71 |
The following data is based on the product molecular weight 458.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
