OAC2 | CAS#6019-39-2 | Oct4-activating

MedKoo Cat#: 526643 | Name: OAC2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.

Chemical Structure

OAC2

CAS#6019-39-2

Theoretical Analysis

MedKoo Cat#: 526643

Name: OAC2

CAS#: 6019-39-2

Chemical Formula: C15H12N2O

Exact Mass: 236.0950

Molecular Weight: 236.27

Elemental Analysis: C, 76.25; H, 5.12; N, 11.86; O, 6.77

Price and Availability

Size	Price	Availability
25mg	USD 150.00	Ready to ship
50mg	USD 250.00	Ready to ship
100mg	USD 425.00	Ready to ship
200mg	USD 750.00	Ready to ship
500mg	USD 1,450.00	Ready to ship
1g	USD 2,450.00	Ready to ship
2g	USD 3,450.00	2 weeks

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Related CAS #

No Data

Synonym

OAC2; OAC-2; OAC 2.

IUPAC/Chemical Name

N-1H-indol-5-yl-benzamide

InChi Key

JCAFGYWSIWYMOX-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H12N2O/c18-15(11-4-2-1-3-5-11)17-13-6-7-14-12(10-13)8-9-16-14/h1-10,16H,(H,17,18)

SMILES Code

O=C(NC1=CC2=C(NC=C2)C=C1)C3=CC=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#BBC60812

QC Data

View QC data: current batch, Lot#BBC60812

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.

In vitro activity:

To localize ORS571-oac2 upon coinoculation and to evaluate its nitrogen-fixing potential, plasmids pXLGD4 (carrying a constitutively expressed lacZ gene) (21) and pRS2002 (carrying a nifH-lacZ fusion) (22) were introduced into ORS571-oac2 by triparental mating with pRK2073 (23) as helper plasmid. Mature wild-type nodules on S. rostrata typically retain a globular shape (Fig. 6 A and B, which is published as supporting information on the PNAS web site), whereas ORS571-oac2-induced nodules continued to develop primordia, resulting in large multilobed structures (Fig. 1A). ORS571-oac2-induced nodules at 60 dpi had multiple blue spots on the surface (Fig. 1 A) that corresponded with colonization of the outermost cortical cells and a limited deeper tissue invasion (Fig. 1B). Upon nodule induction with a GUS-marked ORS571-oac2 (Fig. 2D), plant cells of the infection zone had cyan blue precipitates in the cytoplasm (Fig. 2E). TEM confirmed the presence of bacteria in plant cells that, atypically, still contained several vacuoles (Fig. 2F). Based on these observations, we hypothesize that, in the ORS571-oac2–S. rostrata interaction, the absence of a bacterial signal fails to trigger progression of the symbiotic program of the host. Reference: Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7): 2655–2660. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549025/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	10.0	42.30

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Mathis R, Van Gijsegem F, De Rycke R, D'Haeze W, Van Maelsaeke E, Anthonio E, Van Montagu M, Holsters M, Vereecke D. Lipopolysaccharides as a communication signal for progression of legume endosymbiosis. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2655-60. doi: 10.1073/pnas.0409816102. Epub 2005 Feb 7. PMID: 15699329; PMCID: PMC549025. 2. Wakao S, Siarot L, Aono T, Oyaizu H. Effects of alteration in LPS structure in Azorhizobium caulinodans on nodule development. J Gen Appl Microbiol. 2015;61(6):248-54. doi: 10.2323/jgam.61.248. PMID: 26782655.

In vitro protocol:

In vivo protocol:

TBD