Synonym
S 9977; S-9977; S9977; S-9977-2; S9977-2; S9977-2;
IUPAC/Chemical Name
N,N-diethyl-4-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)propyl)piperazine-1-carboxamide hydrochloride
InChi Key
GVHZRDKDUVIRNY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H33N7O3.ClH/c1-6-26(7-2)20(30)27-13-11-25(12-14-27)10-8-9-15-21-17-16(22(15)3)18(28)24(5)19(29)23(17)4;/h6-14H2,1-5H3;1H
SMILES Code
O=C(N1CCN(CCCC(N2C)=NC(N(C)C(N3C)=O)=C2C3=O)CC1)N(CC)CC.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
455.98
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Trudeau LE, Fossier P, Baux G, Tauc L. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. PubMed PMID: 1380883.
2: Fernández-Novoa L, Alvarez XA, Détolle-Sarbach S, Guez D, Zas R, Polo E, Cacabelos R. Effects of S-9977-2 on histamine levels in rats. Methods Find Exp Clin Pharmacol. 1996 Apr;18(3):197-203. PubMed PMID: 8738071.
3: Schroeder H, Dumont I, Boyet S, Mocaër E, Nehlig A. Effects of the acute administration of a new trimethylxanthine derivative, S 9977-2, on local cerebral blood flow and glucose utilization in the rat. Eur J Pharmacol. 1992 Sep 22;220(2-3):217-29. PubMed PMID: 1425993.
4: Boulanger CM, Hughes H, Bond RA, Rafla E, Vanhoutte PM. Effects of S9977 on adrenergic neurotransmission. Gen Pharmacol. 1993 Mar;24(2):429-34. PubMed PMID: 8387054.
5: Villalón CM, Bom AH, Den Boer MO, Heiligers JP, Saxena PR. Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacol Res. 1992 Feb-Mar;25(2):125-37. PubMed PMID: 1635891.
