D3S-001 is a KRAS G12C inhibitor. D3S-001 is a next generation GDP-bound G12C inhibitor with faster target engagement (TE) kinetics that depletes cellular active KRAS G12C at nanomolar concentrations. The high covalent potency and cellular TE efficiency of D3S-001 contributes to robust anti-tumor activity preclinically.
MedKoo Cat#: 145196
Name: D3S-001
CAS#: 2706637-43-4
Chemical Formula: C32H35F6N7O3
Exact Mass: 679.2706
Molecular Weight: 679.67
Elemental Analysis: C, 56.55; H, 5.19; F, 16.77; N, 14.43; O, 7.06
The following data is based on the product molecular weight 679.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
