MedKoo Cat#: 564205 | Name: JAK3 Inhibitor VI
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).

Chemical Structure

JAK3 Inhibitor VI
JAK3 Inhibitor VI
CAS#856436-16-3

Theoretical Analysis

MedKoo Cat#: 564205

Name: JAK3 Inhibitor VI

CAS#: 856436-16-3

Chemical Formula: C19H17N3O4S

Exact Mass: 383.0940

Molecular Weight: 383.42

Elemental Analysis: C, 59.52; H, 4.47; N, 10.96; O, 16.69; S, 8.36

Price and Availability

Size Price Availability Quantity
5mg USD 415.00
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Synonym
JAK3 Inhibitor VI; JAK-3 Inhibitor VI; JAK 3 Inhibitor VI
IUPAC/Chemical Name
(Z)-3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one Mesylate
InChi Key
ZUDPNBZMAJGYTE-HYMQDMCPSA-N
InChi Code
InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;
SMILES Code
O=C1NC2=C(C=C(C3=CC=CN=C3)C=C2)/C1=C/C4=CC=CN4.OS(=O)(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem. 2015 Nov 26;6(4):409-18. doi: 10.4331/wjbc.v6.i4.409. PubMed PMID: 26629323; PubMed Central PMCID: PMC4657120.