Synonym
Protriptyline Hydrochloride; Concordin; Maximed; Triptyl; Protriptyline HCl; Triptil hydrochloride; Hydrochloride, Protriptyline; Odyssey Brand of Protriptyline Hydrochloride; Protriptyline; Protriptyline Hydrochloride ; Vivactil;
IUPAC/Chemical Name
3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine;hydrochloride
InChi Key
OGQDIIKRQRZXJH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
SMILES Code
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
299.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. doi: 10.3109/10799893.2014.1000464. Epub 2015 Jun 22. PubMed PMID: 26096164.
2: Bansode SB, Jana AK, Batkulwar KB, Warkad SD, Joshi RS, Sengupta N, Kulkarni MJ. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. doi: 10.1371/journal.pone.0105196. eCollection 2014. PubMed PMID: 25141174; PubMed Central PMCID: PMC4139341.
3: Jo SH, Hong HK, Chong SH, Choe H. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life Sci. 2008 Jan 30;82(5-6):331-40. doi: 10.1016/j.lfs.2007.12.004. Epub 2008 Jan 11. PubMed PMID: 18191158.
4: Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest. 1991 Aug;100(2):416-21. PubMed PMID: 1864117.
5: Saef MA, Yilanli M, Saadabadi A. Protriptyline. 2023 Aug 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29763003.
6: Walker ST. Liquid chromatographic determination of organic nitrogenous bases in dosage forms: a progress report. J Assoc Off Anal Chem. 1985 May- Jun;68(3):539-42. PMID: 4019383.
7: Clark RW, Schmidt HS, Schuller DE. Sleep-induced ventilatory dysfunction in Down's syndrome. Arch Intern Med. 1980 Jan;140(1):45-50. PMID: 6444353.
8: Ziegler VE, Biggs JT, Wylie LT, Coryell WH, Hanifl KM, Hawf DJ, Rosen SH. Protriptyline kinetics. Clin Pharmacol Ther. 1978 May;23(5):580-4. doi: 10.1002/cpt1978235580. PMID: 639433.
9: FELDMAN PE. PROTRIPTYLINE HYDROCHLORIDE (TRIPTIL)--A NEW ANTIDEPRESSANT. Psychosomatics. 1964 Mar-Apr;5:96-101. doi: 10.1016/s0033-3182(64)72460-7. PMID: 14130889.
