PD 124816 | CAS# 112654-98-5 | quinolone antibacterial

MedKoo Cat#: 414805 | Name: PD 124816

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 124816 is a quinolone antibacterial that was undergoing preclinical development with Parke-Davis (USA).

Chemical Structure

PD 124816

CAS#112654-98-5

Theoretical Analysis

MedKoo Cat#: 414805

Name: PD 124816

CAS#: 112654-98-5

Chemical Formula: C17H18F2N4O3

Exact Mass: 364.1347

Molecular Weight: 364.35

Elemental Analysis: C, 56.04; H, 4.98; F, 10.43; N, 15.38; O, 13.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PD 124816; PD124816; PD-124816

IUPAC/Chemical Name

3-Quinolinecarboxylic acid, 1,4-dihydro-5-amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-4-oxo-

InChi Key

GMCYYXZTVSSTQW-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H18F2N4O3/c18-11-13(21)10-14(12(19)15(11)22-4-3-7(20)5-22)23(8-1-2-8)6-9(16(10)24)17(25)26/h6-8H,1-5,20-21H2,(H,25,26)

SMILES Code

O=C(C1=CN(C2CC2)C3=C(C(N)=C(F)C(N4CC(N)CC4)=C3F)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cohen MA, Huband MD, Mailloux GB, Yoder SL, Roland GE, Heifetz CL. In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis. 1991 May-Jun;14(3):245-58. doi: 10.1016/0732-8893(91)90039-i. PMID: 1889177. 2: Curry PT, Kropko ML, Garvin JR, Fiedler RD, Theiss JC. In vitro induction of micronuclei and chromosome aberrations by quinolones: possible mechanisms. Mutat Res. 1996 Jun 10;352(1-2):143-50. doi: 10.1016/0027-5107(96)00002-4. PMID: 8676903. 3: Franzblau SG, White KE. Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae. Antimicrob Agents Chemother. 1990 Feb;34(2):229-31. doi: 10.1128/AAC.34.2.229. PMID: 2183714; PMCID: PMC171562. 4: Gelber RH, Iranmanesh A, Murray L, Siu P, Tsang M. Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice. Antimicrob Agents Chemother. 1992 Nov;36(11):2544-7. doi: 10.1128/AAC.36.11.2544. PMID: 1336951; PMCID: PMC284372. 5: Domagala JM, Hagen SE, Hutt MP, Sanchez JP, Sesnie J, Trehan AK. 5-Amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid (PD 124,816). Synthesis and biological evaluation of a new class of quinolone antibacterials. Drugs Exp Clin Res. 1988;14(7):453-60. PMID: 2853667.