Synonym
MSI-2216; MSI 2216; MSI2216
IUPAC/Chemical Name
1(3H)-Isobenzofuranone, 3-(2-oxo-2-(2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinyl)ethyl)-
InChi Key
FPUWITQFSOFORR-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H15F3N2O3/c23-22(24,25)13-5-3-6-14(11-13)27-20-17(9-4-10-26-20)18(28)12-19-15-7-1-2-8-16(15)21(29)30-19/h1-11,19H,12H2,(H,26,27)
SMILES Code
O=C1OC(CC(C2=CC=CN=C2NC3=CC=CC(C(F)(F)F)=C3)=O)C4=C1C=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
412.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hauber HP, Daigneault P, Frenkiel S, Lavigne F, Hung HL, Levitt RC, Hamid Q. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J Allergy Clin Immunol. 2005 Feb;115(2):266-71. doi: 10.1016/j.jaci.2004.09.039. PMID: 15696080.
2: Hauber HP, Goldmann T, Vollmer E, Wollenberg B, Hung HL, Levitt RC, Zabel P. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors. J Endotoxin Res. 2007;13(2):109-16. doi: 10.1177/0968051907079168. PMID: 17621552.
3: Hauber HP, Steffen A, Goldmann T, Vollmer E, Hung HL, Wollenberg B, Zabel P. Effect of steroids, acetyl-cysteine and calcium-activated chloride channel inhibitors on allergic mucin expression in sinus mucosa. Laryngoscope. 2008 Sep;118(9):1528-33. doi: 10.1097/MLG.0b013e31817b0732. PMID: 18596559.
