Ropivacaine monohydrochloride | CAS# 98717-15-8 | Biochemical

MedKoo Cat#: 577976 | Name: Ropivacaine monohydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ropivacaine monohydrochloride is an amide local anesthetic with characteristics similar to bupivacaine.

Chemical Structure

Ropivacaine monohydrochloride

CAS#98717-15-8

Theoretical Analysis

MedKoo Cat#: 577976

Name: Ropivacaine monohydrochloride

CAS#: 98717-15-8

Chemical Formula: C17H27ClN2O

Exact Mass: 310.1812

Molecular Weight: 310.87

Elemental Analysis: C, 65.68; H, 8.75; Cl, 11.40; N, 9.01; O, 5.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Naropin HCl; Naropin hydrochloride; Ropivacaine monohydrochloride; Ropivacaine hydrochloride; Ropivacaine HCl

IUPAC/Chemical Name

2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, monohydrochloride, (S)-

InChi Key

NDNSIBYYUOEUSV-RSAXXLAASA-N

InChi Code

InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H/t15-;/m0./s1

SMILES Code

Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 310.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brydone AS, Souvatzoglou R, Abbas M, Watson DG, McDonald DA, Gill AM. Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty. Anaesthesia. 2015 Jul;70(7):784-90. doi: 10.1111/anae.13017. Epub 2015 Feb 22. PubMed PMID: 25708670. 2: Hübler M, Planitz MC, Vicent O. Early pharmacokinetic of ropivacaine without epinephrine after injection into the psoas compartment. Br J Anaesth. 2015 Jan;114(1):130-5. doi: 10.1093/bja/aeu363. Epub 2014 Oct 10. PubMed PMID: 25303987. 3: Budharapu A, Sinha R, Uppada UK, Subramanya Kumar AV. Ropivacaine: a new local anaesthetic agent in maxillofacial surgery. Br J Oral Maxillofac Surg. 2015 May;53(5):451-4. doi: 10.1016/j.bjoms.2015.02.021. Epub 2015 Mar 24. PubMed PMID: 25818492. 4: Koköfer A, Nawratil J, Felder TK, Stundner O, Mader N, Gerner P. Ropivacaine 0.375% vs. 0.75% with prilocaine for intermediate cervical plexus block for carotid endarterectomy: A randomised trial. Eur J Anaesthesiol. 2015 Nov;32(11):781-9. doi: 10.1097/EJA.0000000000000243. PubMed PMID: 25782662. 5: Murouchi T, Iwasaki S, Yamakage M. Chronological Changes in Ropivacaine Concentration and Analgesic Effects Between Transversus Abdominis Plane Block and Rectus Sheath Block. Reg Anesth Pain Med. 2015 Sep-Oct;40(5):568-71. doi: 10.1097/AAP.0000000000000288. PubMed PMID: 26222347. 6: Choromanski DW, Patel PS, Frederick JM, Lemos SE, Chidiac EJ. The effect of continuous interscalene brachial plexus block with 0.125% bupivacaine vs 0.2% ropivacaine on pain relief, diaphragmatic motility, and ventilatory function. J Clin Anesth. 2015 Dec;27(8):619-26. doi: 10.1016/j.jclinane.2015.03.006. Epub 2015 Jul 26. PubMed PMID: 26216250. 7: Li H, Li Y, He R. Sparing effects of sufentanil on epidural ropivacaine in elderly patients undergoing transurethral resection of prostate surgery. Yonsei Med J. 2015 May;56(3):832-7. doi: 10.3349/ymj.2015.56.3.832. PubMed PMID: 25837193; PubMed Central PMCID: PMC4397457. 8: Roelants F, Lavand'homme P. Clonidine versus sufentanil as an adjuvant to ropivacaine in patient-controlled epidural labour analgesia: A randomised double-blind trial. Eur J Anaesthesiol. 2015 Nov;32(11):805-11. doi: 10.1097/EJA.0000000000000347. PubMed PMID: 26426577. 9: Raines S, Hedlund C, Franzon M, Lillieborg S, Kelleher G, Ahlén K. Ropivacaine for continuous wound infusion for postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Eur Surg Res. 2014;53(1-4):43-60. doi: 10.1159/000363233. Epub 2014 Jul 23. Review. PubMed PMID: 25060049. 10: Zhou Y, He M, Zou T, Yu B. Morphological changes in the sciatic nerve, skeletal muscle, heart and brain of rabbits receiving continuous sciatic nerve block with 0.2% ropivacaine. Int J Clin Exp Pathol. 2015 Nov 1;8(11):13911-20. eCollection 2015. PubMed PMID: 26823703; PubMed Central PMCID: PMC4713489. 11: Yamashiro M, Hashimoto S, Yasuda A, Sunada K. Epinephrine Affects Pharmacokinetics of Ropivacaine Infiltrated Into Palate. Anesth Prog. 2016 Summer;63(2):71-9. doi: 10.2344/0003-3006-63.2.71. PubMed PMID: 27269664; PubMed Central PMCID: PMC4896045. 12: Kitayama M, Wada M, Hashimoto H, Kudo T, Yakoshi C, Hirota K. Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy. J Anesth. 2014 Aug;28(4):576-9. doi: 10.1007/s00540-013-1763-9. Epub 2013 Dec 18. PubMed PMID: 24347034. 13: Costa-Martins JM, Dias CC, Pereira M, Tavares J. Effects of local anesthetic on the time between analgesic boluses and the duration of labor in patient-controlled epidural analgesia: prospective study of two ultra-low dose regimens of ropivacaine and sufentanil. Acta Med Port. 2015 Jan-Feb;28(1):70-6. Epub 2015 Feb 27. PubMed PMID: 25817501. 14: Ginosar Y, Haroutounian S, Kagan L, Naveh M, Aharon A, Davidson EM. Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers. Anesth Analg. 2016 May;122(5):1673-80. doi: 10.1213/ANE.0000000000001217. PubMed PMID: 27057798. 15: Abimussi CJ, Menegheti TM, Wagatsuma JT, Floriano BP, Arruda AM, dos Santos PS, Oliva VN. Tumescent local anesthesia with ropivacaine in different concentrations in bitches undergoing mastectomy: plasma concentration and post-operative analgesia. Vet Anaesth Analg. 2014 Sep;41(5):516-25. doi: 10.1111/vaa.12178. Epub 2014 May 17. PubMed PMID: 24835303. 16: Rohan B, Singh PY, Gurjeet K. Addition of clonidine or lignocaine to ropivacaine for supraclavicular brachial plexus block: a comparative study. Singapore Med J. 2014 Apr;55(4):229-32. PubMed PMID: 24763840; PubMed Central PMCID: PMC4291952. 17: Gill AM, Scott NB, Abbas M, Watson DG, Place K, McDonald DA. Ropivacaine plasma levels following local infiltration analgesia for primary total hip arthroplasty. Anaesthesia. 2014 Apr;69(4):368-73. doi: 10.1111/anae.12559. PubMed PMID: 24641643. 18: Chavarría-Pérez T, Cabrera-Leal CF, Ramírez-Vargas S, Reynada JL, Arce-Salinas CA. [Locally administered ropivacaine vs. standard analgesia for laparoscopic cholecystectomy]. Rev Med Inst Mex Seguro Soc. 2015 May-Jun;53(3):274-8. Spanish. PubMed PMID: 25984611. 19: Davidson EM, Haroutounian S, Kagan L, Naveh M, Aharon A, Ginosar Y. A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs. Anesth Analg. 2016 May;122(5):1663-72. doi: 10.1213/ANE.0000000000001200. PubMed PMID: 27057797. 20: Thomassen BJ, Touw D, van der Woude P, van der Flier RE, In 't Veld BA. Safety of blood reinfusion after local infiltration analgesia with ropivacaine in total knee arthroplasty. Int J Clin Pharmacol Ther. 2014 Feb;52(2):135-42. doi: 10.5414/CP201965. PubMed PMID: 24361087.