Canocapavir | CAS# 2137847-19-7 | Antiviral

MedKoo Cat#: 121068 | Name: Canocapavir

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Canocapavir is an antiviral. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B.

Chemical Structure

Canocapavir

CAS#2137847-19-7

Theoretical Analysis

MedKoo Cat#: 121068

Name: Canocapavir

CAS#: 2137847-19-7

Chemical Formula: C27H21BrFN5O3

Exact Mass: 561.0812

Molecular Weight: 562.40

Elemental Analysis: C, 57.66; H, 3.76; Br, 14.21; F, 3.38; N, 12.45; O, 8.53

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 1,250.00	2 Weeks
10mg	USD 2,050.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Canocapavir; ZM-H1505R; ZMH1505R; ZM H1505R

IUPAC/Chemical Name

5-(2-{(2R)-2-[1-(4-bromophenyl)-3-(4-fluorophenyl)-1Hpyrazol- 4-yl]-4-oxo-1,3-oxazolidin-3-yl}ethyl)-1,3- dihydro-2H-benzimidazol-2-one

InChi Key

YGPZZDKSASSELG-AREMUKBSSA-N

InChi Code

InChI=1S/C27H21BrFN5O3/c28-18-4-8-20(9-5-18)34-14-21(25(32-34)17-2-6-19(29)7-3-17)26-33(24(35)15-37-26)12-11-16-1-10-22-23(13-16)31-27(36)30-22/h1-10,13-14,26H,11-12,15H2,(H2,30,31,36)/t26-/m1/s1

SMILES Code

O=C(N1)NC2=C1C=CC(CCN3[C@@]([H])(C4=CN(C5=CC=C(Br)C=C5)N=C4C6=CC=C(F)C=C6)OCC3=O)=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 562.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zheng Y, Yang L, Yu L, Zhu Y, Wu Y, Zhang Z, Xia T, Deng Q. Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein. Viruses. 2023 May 18;15(5):1195. doi: 10.3390/v15051195. PMID: 37243280; PMCID: PMC10223407. 2: Jia H, Mai J, Wu M, Chen H, Li X, Li C, Liu J, Liu C, Hu Y, Zhu X, Jiang X, Hua B, Xia T, Liu G, Deng A, Liang B, Guo R, Lu H, Wang Z, Chen H, Zhang Z, Zhang H, Niu J, Ding Y. Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial. BMC Med. 2023 Mar 16;21(1):98. doi: 10.1186/s12916-023-02814-w. PMID: 36927420; PMCID: PMC10022191. 3: Jiang X, Hua B, Liu G, Xia T, Deng A, Lu H, Guo R, Wang Z, Liang B, Chen H, Jin Q, Zhang Z. Safety, Tolerability, and Pharmacokinetics of a Novel Human Hepatitis B Virus Capsid Assembly Modulator Canocapavir: A Randomized First-in- Human Study. Gastro Hep Adv. 2023 Jan 7;2(4):524-531. doi: 10.1016/j.gastha.2023.01.001. PMID: 39132049; PMCID: PMC11307714.