Propylhexedrine HCl | CAS#1007-33-6 | adrenergic agonist

MedKoo Cat#: 318591 | Name: Propylhexedrine HCl

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propylhexedrine is an alpha-adrenergic stimulant used extensively in nasal decongestant inhalers. Propylhexedrine works mainly as an adrenergic agonist, when used at therapeutic doses in an inhaler dosage form. This restricts the blood vessels in the nose and reduces swelling; thereby, the product relieves nasal congestion. At higher doses, propylhexedrine affects the central nervous system as a norepinephrine–dopamine releasing agent. Propylhexedrine likely exerts such effects in a manner similar to related alkylamines such as cyclopentamine, methylhexanamine, and tuaminoheptane. In addition, propylhexedrine further releases monoamines through TAAR1 agonism and VMAT2 inhibition. Propylhexedrine also exhibits antihypotensive effects.

Chemical Structure

Propylhexedrine HCl

CAS#1007-33-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 318591

Name: Propylhexedrine HCl

CAS#: 1007-33-6 (HCl)

Chemical Formula: C10H22ClN

Exact Mass: 0.0000

Molecular Weight: 191.74

Elemental Analysis: C, 62.64; H, 11.56; Cl, 18.49; N, 7.30

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 550.00	2 Weeks
50mg	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

1007-33-6 (HCl) 101-40-6 (free base)

Synonym

Propylhexedrine Hydrochloride; Eventin HCl; Benzedrex; Eggobesin; Benzedrex HCl; propylhexedrine HCl; NSC 170998; NSC 27110;

IUPAC/Chemical Name

1-cyclohexyl-N-methylpropan-2-amine;hydrochloride

InChi Key

WLEGHNSHAIHZPS-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H21N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h9-11H,3-8H2,1-2H3;1H

SMILES Code

CC(CC1CCCCC1)NC.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 191.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fernandez Julia P, Francis EM. Propylhexedrine: a vintage drug of abuse, rediscovered. J Psychoactive Drugs. 2012 Jul-Aug;44(3):277-9. PubMed PMID: 23061329. 2: Holler JM, Vorce SP, McDonough-Bender PC, Magluilo J Jr, Solomon CJ, Levine B. A drug toxicity death involving propylhexedrine and mitragynine. J Anal Toxicol. 2011 Jan;35(1):54-9. PubMed PMID: 21219704. 3: Perez J, Burton BT, McGirr JG. Airway compromise and delayed death following attempted central vein injection of propylhexedrine. J Emerg Med. 1994 Nov-Dec;12(6):795-7. PubMed PMID: 7533806. 4: Iven H, Feldbusch E. Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(2):153-9. PubMed PMID: 6139756. 5: Croft CH, Firth BG, Hillis LD. Propylhexedrine-induced left ventricular dysfunction. Ann Intern Med. 1982 Oct;97(4):560-1. PubMed PMID: 6127046. 6: Liggett SB. Propylhexedrine Intoxication: Clinical Presentation and Pharmacology. South Med J. 1982 Feb;75(2):250-1. PubMed PMID: 6120574. 7: White L, DiMaio VJ. Intravenous propylhexedrine and sudden death. N Engl J Med. 1977 Nov 10;297(19):1071. PubMed PMID: 20578. 8: DiMaio VJ, Garriott JC. Intravenous abuse of propylhexedrine. J Forensic Sci. 1977 Jan;22(1):152-8. PubMed PMID: 45496. 9: Sturner WQ, Spruill FG, Garriott JC. Two propylhexedrine-associated fatalities: Benzedrine revisited. J Forensic Sci. 1974 Jul;19(3):572-4. PubMed PMID: 4137337. 10: Appel W, Sprengard D. [Pharmacokinetics of propylhexedrine]. Arzneimittelforschung. 1971 Jun;21(6):894-9. German. PubMed PMID: 5109288. 11: Anderson ED. Propylhexedrine (Benzedrex) psychosis. N Z Med J. 1970 May;71(456):302. PubMed PMID: 5270979. 12: Dick RW, Mitchell CL. A comparison of the anticonvulsant properties of l-propylhexedrine, phenobarbital and a salt-like complex of l-propylhexedrine and phenobarbital in mice and rats. Arch Int Pharmacodyn Ther. 1967 Dec;170(2):333-42. PubMed PMID: 6076581. 13: POLSTER H. [ON POISONING WITH THE APPETITE DEPRESSANT PROPYLHEXEDRINE, "OBESIN" IN A 3-YEAR-OLD CHILD]. Arch Toxikol. 1965 Feb 10;20:271-3. German. PubMed PMID: 14272412. 14: Smith DE, Wesson DR, Sees KL, Morgan JP. An epidemiological and clinical analysis of propylhexedrine abuse in the United States. J Psychoactive Drugs. 1988 Oct-Dec;20(4):441-2. PubMed PMID: 2907528. 15: Covey DC, Nossaman BD, Albright JA. Ischemic injury of the hand from intra-arterial propylhexedrine injection. J Hand Surg Am. 1988 Jan;13(1):58-61. PubMed PMID: 2895132. 16: Fornazzari L, Carlen PL, Kapur BM. Intravenous abuse of propylhexedrine (Benzedrex) and the risk of brainstem dysfunction in young adults. Can J Neurol Sci. 1986 Nov;13(4):337-9. PubMed PMID: 2877725. 17: Perucca E, Grimaldi R, Ruberto G, Gelmi C, Trimarchi F, Crema A. Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone). Eur J Clin Pharmacol. 1986;29(6):729-30. PubMed PMID: 3709618. 18: Mancusi-Ungaro HR Jr, Decker WJ, Forshan VR, Blackwell SJ, Lewis SR. Tissue injuries associated with parenteral propylhexedrine abuse. J Toxicol Clin Toxicol. 1983-1984;21(3):359-72. PubMed PMID: 6144800. 19: Hamilton LH. Nasal decongestant effect of propylhexedrine. Ann Otol Rhinol Laryngol. 1982 Jan-Feb;91(1 Pt 1):106-11. PubMed PMID: 6176171. 20: Riddick L, Reisch R. Oral overdose of propylhexedrine. J Forensic Sci. 1981 Oct;26(4):834-9. PubMed PMID: 6117600.