CB-03-10 | AR/GR dual inhibitor | CAS# 1902166-22-6

MedKoo Cat#: 126351 | Name: CB-03-10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CB-03-10 is an AR/GR dual inhibitor.

Chemical Structure

CB-03-10

CAS# 1902166-22-6

Theoretical Analysis

MedKoo Cat#: 126351

Name: CB-03-10

CAS#: 1902166-22-6

Chemical Formula: C29H42O6

Exact Mass: 486.2981

Molecular Weight: 486.65

Elemental Analysis: C, 71.57; H, 8.70; O, 19.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CB-03-10; CB03-10; CB 03-10; CB0310

IUPAC/Chemical Name

Cortexolone 17α-valerate-21-propionate

InChi Key

GCTWGWYGNBWXHM-APKWJLQYSA-N

InChi Code

InChI=1S/C29H42O6/c1-5-7-8-26(33)35-29(24(31)18-34-25(32)6-2)16-13-23-21-10-9-19-17-20(30)11-14-27(19,3)22(21)12-15-28(23,29)4/h17,21-23H,5-16,18H2,1-4H3/t21-,22+,23+,27+,28+,29+/m1/s1

SMILES Code

O=C1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@](C(COC(CC)=O)=O)(OC(CCCC)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 486.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Rosette C, Agan FJ, Rosette N, Mazzetti A, Moro L, Gerloni M. The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade. Mol Cancer Ther. 2020 Nov;19(11):2256-2266. doi: 10.1158/1535-7163.MCT-19-1137. Epub 2020 Aug 26. PMID: 32847976.