Propylhexedrine is an alpha-adrenergic stimulant used extensively in nasal decongestant inhalers. Propylhexedrine works mainly as an adrenergic agonist, when used at therapeutic doses in an inhaler dosage form. This restricts the blood vessels in the nose and reduces swelling; thereby, the product relieves nasal congestion. At higher doses, propylhexedrine affects the central nervous system as a norepinephrine–dopamine releasing agent. Propylhexedrine likely exerts such effects in a manner similar to related alkylamines such as cyclopentamine, methylhexanamine, and tuaminoheptane. In addition, propylhexedrine further releases monoamines through TAAR1 agonism and VMAT2 inhibition. Propylhexedrine also exhibits antihypotensive effects.
MedKoo Cat#: 412847
Name: Propylhexedrine free base
CAS#: 101-40-6 (free base)
Chemical Formula: C10H21N
Exact Mass: 155.1674
Molecular Weight: 155.29
Elemental Analysis: C, 77.35; H, 13.63; N, 9.02
The following data is based on the product molecular weight 155.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
