MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 318574 | Name: Procaterol hydrochloride
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Procaterol hydrochloride is a specific and very potent β2-AR agonist. It acts as a vasodialator for long term treatment of asthma.

Chemical Structure

Procaterol hydrochloride
Procaterol hydrochloride
CAS#62929-91-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 318574

Name: Procaterol hydrochloride

CAS#: 62929-91-3 (HCl)

Chemical Formula: C16H23ClN2O3

Exact Mass: 326.1397

Molecular Weight: 326.82

Elemental Analysis: C, 58.80; H, 7.09; Cl, 10.85; N, 8.57; O, 14.69

Price and Availability

Size Price Availability Quantity
10mg USD 425.00 2 Weeks
25mg USD 750.00 2 Weeks
50mg USD 1,200.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
59828-07-8 (HCl) 62929-91-3 (HCl) 72332-33-3 (free base) 81262-93-3 (HCl hemihydrate)
Synonym
Procaterol Hydrochloride; OPC 2009; OPC-2009; OPC2009; CI 888; CI-888; CI888.
IUPAC/Chemical Name
8-hydroxy-5-[(1R,2S)-1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;hydrochloride
InChi Key
AEQDBKHAAWUCMT-CVHDTDHSSA-N
InChi Code
InChI=1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1
SMILES Code
CCC(C(C1=C2C=CC(=O)NC2=C(C=C1)O)O)NC(C)C.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Procaterol hydrochloride is a specific and very potent β2-AR agonist.
In vitro activity:
This study evaluated procaterol and dexamethasone in the hydrogen peroxide (H2O2)-induced immortal human bronchial epithelial cell model of oxidative stress and investigated the underlying mechanisms. Results showed that exposure to 125 μM H2O2 for 2 h led to a 50% reduction in the cell viability, significantly increased the percentage of apoptosis, and elevated levels of malondialdehyde and reactive oxygen species. Pretreatment with procaterol (25 - 200 nM) could reduce these effects in a dose-dependent manner. In contrast, pretreatment with dexamethasone (100 nM, 1000 nM) was inefficient. Reference: J Pharmacol Sci. 2014;125(1):39-50. https://pubmed.ncbi.nlm.nih.gov/24739282/
In vivo activity:
Three intervention groups were investigated: a procaterol inhalation only group; a procaterol inhalation plus endotoxin injection mouse group (in vivo); and a procaterol incubation group (in vitro). The diaphragm muscle in all groups was dissected and measurements of its contractile properties were performed. The effects of procaterol inhalation shifted the force-frequency curves upward at 30 minutes after inhalation, and inhibited the decline of force-frequency curves due to endotoxin injection in vivo. Reference: Allergol Int. 2007 Sep;56(3):285-91. https://pubmed.ncbi.nlm.nih.gov/17646734/
Solvent mg/mL mM
Solubility
Ethanol 3.0 9.18
Water 48.8 149.44
Ethanol 3.0 9.18
Water 48.8 149.44
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 326.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Deng Z, Zhou JJ, Sun SY, Zhao X, Sun Y, Pu XP. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. doi: 10.1254/jphs.13206fp. Epub 2014 Apr 16. PMID: 24739282. 2. Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuda H, Deng X, Sasaki T, Kubo H, Nagatomi R. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. doi: 10.1016/j.ejphar.2010.09.056. Epub 2010 Oct 15. PMID: 20940011. 3. Shindoh C, Sasaki K, Shindoh Y, Tamura G. Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. doi: 10.2332/allergolint.O-06-463. Epub 2007 Aug 1. PMID: 17646734. 4. Tashimo H, Yamashita N, Ishida H, Nagase H, Adachi T, Nakano J, Yamamura K, Yano T, Yoshihara H, Ohta K. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. doi: 10.2332/allergolint.O-06-456. Epub 2007 Jul 1. PMID: 17582211.
In vitro protocol:
1. Deng Z, Zhou JJ, Sun SY, Zhao X, Sun Y, Pu XP. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. doi: 10.1254/jphs.13206fp. Epub 2014 Apr 16. PMID: 24739282. 2. Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuda H, Deng X, Sasaki T, Kubo H, Nagatomi R. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. doi: 10.1016/j.ejphar.2010.09.056. Epub 2010 Oct 15. PMID: 20940011.
In vivo protocol:
1. Shindoh C, Sasaki K, Shindoh Y, Tamura G. Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. doi: 10.2332/allergolint.O-06-463. Epub 2007 Aug 1. PMID: 17646734. 2. Tashimo H, Yamashita N, Ishida H, Nagase H, Adachi T, Nakano J, Yamamura K, Yano T, Yoshihara H, Ohta K. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. doi: 10.2332/allergolint.O-06-456. Epub 2007 Jul 1. PMID: 17582211.
1: Liu X, Dong Y, Lv W. Value exploration of treating pediatric pneumonia with ambroxol hydrochloride and procaterol hydrochloride. Minerva Pediatr (Torino). 2024 Feb;76(1):145-147. doi: 10.23736/S2724-5276.23.07341-X. Epub 2023 Jun 16. PMID: 37335187. 2: Kong L, Zhao Y, Wang Y, Chang X, Cui L, Gu G, Ma Z, Lu Q, Zhou L, Ding L, Wang Z, Shao Y, Tang H, Zhang C, Hui F, Mei X, Xin J, Huo J, Sun S, Zhu S, Yao C, Du G, Cheng M, Kang J. Efficacy and safety of tratinterol hydrochloride tablets in bronchial asthma: a randomized double-blind and multicenter clinical trial. J Asthma. 2021 Jan;58(1):85-92. doi: 10.1080/02770903.2019.1663427. Epub 2019 Oct 14. PMID: 31514546. 3: Kong D, Han L, Wang Z, Jiang L, Zhang Q, Wu Q, Su J, Lu C, Chen G. An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi- walled carbon nanotube for the determination of bromhexine hydrochloride. RSC Adv. 2019 Apr 16;9(21):11901-11911. doi: 10.1039/c8ra08510b. PMID: 35516997; PMCID: PMC9063560. 4: Kong D, Zhuang Q, Han Y, Xu L, Wang Z, Jiang L, Su J, Lu CH, Chi Y. Simultaneous voltammetry detection of dopamine and uric acid in human serum and urine with a poly(procaterol hydrochloride) modified glassy carbon electrode. Talanta. 2018 Aug 1;185:203-212. doi: 10.1016/j.talanta.2018.03.078. Epub 2018 Mar 27. PMID: 29759190. 5: Shirai R, Suzaki Y, Sato K, Takeuchi Y, Tokimatsu I, Koga N, Kadota J, Ohashi K. Evaluation of Bioequivalence Between the New Procaterol Hydrochloride Hydrate Dry Powder Inhaler and the Approved Dry Powder Inhaler in Patients With Asthma in a Randomized, Double-Blind, Double-Dummy, Crossover Comparison Study: A Phase 3 Study. Clin Pharmacol Drug Dev. 2018 May;7(4):392-399. doi: 10.1002/cpdd.379. Epub 2017 Sep 8. PMID: 28884969; PMCID: PMC5947263. 6: Burioka N, Nakamoto S, Amisaki T, Horie T, Shimizu E. A Modified Method for Examining the Walking Pattern and Pace of COPD Patients in a 6-min Walk Test Before and After the Inhalation of Procaterol. Intern Med. 2017;56(15):1949-1955. doi: 10.2169/internalmedicine.56.7961. Epub 2017 Aug 1. PMID: 28768962; PMCID: PMC5577068. 7: Kong D, Jiang L, Liu Y, Wang Z, Han L, Lv R, Lin J, Lu CH, Chi Y, Chen G. Electrochemical investigation and determination of procaterol hydrochloride on poly(glutamic acid)/carboxyl functionalized multiwalled carbon nanotubes/polyvinyl alcohol modified glassy carbon electrode. Talanta. 2017 Nov 1;174:436-443. doi: 10.1016/j.talanta.2017.06.047. Epub 2017 Jun 21. PMID: 28738604. 8: Kong D, Hu F, Jiang L, Lin J, Wei Q, Chi Y, Chen G. Exploring the electrochemiluminescent behavior of procaterol hydrochloride in the presence of Ru(bpy)32+ and its analytical application in pharmaceutical preparation. Luminescence. 2017 Aug;32(5):745-750. doi: 10.1002/bio.3245. Epub 2016 Nov 15. PMID: 27862870. 9: Tahara K, Tomida H, Ito Y, Tachikawa S, Onodera R, Tanaka H, Tozuka Y, Takeuchi H. Pulmonary liposomal formulations encapsulated procaterol hydrochloride by a remote loading method achieve sustained release and extended pharmacological effects. Int J Pharm. 2016 May 30;505(1-2):139-46. doi: 10.1016/j.ijpharm.2016.03.031. Epub 2016 Mar 21. PMID: 27012982. 10: Yanagida N, Tomikawa M, Shukuya A, Iguchi M, Ebisawa M. Budesonide inhalation suspension versus methylprednisolone for treatment of moderate bronchial asthma attacks. World Allergy Organ J. 2015 May 5;8(1):14. doi: 10.1186/s40413-015-0065-0. PMID: 25977745; PMCID: PMC4419502. 11: Kong L, Liu J, Gu G, Huo J, Ma Z, Shao Y, Sun S, Yuan Y, Zhu S, Yao C, Du G, Cheng M, Kang J. Randomized, Multicenter Clinical Study of Tratinterol Hydrochloride Tablets for the Treatment of Bronchial Asthma. Clin Ther. 2015 Jun 1;37(6):1248-58. doi: 10.1016/j.clinthera.2015.03.013. Epub 2015 Apr 7. PMID: 25857594. 12: Nishikawa A, Mori-Yoshimura M, Okamoto T, Oya Y, Nakata T, Ohno K, Murata M. [Beneficial effects of 3,4-diaminopyridine in a 26-year-old woman with DOK7 congenital myasthenic syndrome who was originally diagnosed with facioscapulohumeral dystrophy]. Rinsho Shinkeigaku. 2014;54(7):561-4. Japanese. doi: 10.5692/clinicalneurol.54.561. PMID: 25087557. 13: Liu JM, Huang Q, Liu ZB, Zhang LH, Zheng ZY, Lin CQ. Design of highly sensitive phosphorescence sensor for determination of procaterol hydrochloride based on inhibition of KClO3 oxidation fluorescein isothiocyanate. Luminescence. 2015 Jun;30(4):382-7. doi: 10.1002/bio.2743. Epub 2014 Jul 18. PMID: 25044504. 14: Deng Z, Gao ZC, Ge HQ, Zhang LR, Zhou JJ, Zhu ZP, Wu DY, Sun SY, Chen L, Pu XP. Treatment responses of procaterol and CD38 inhibitors in an ozone-induced airway hyperresponsiveness mice model. Biol Pharm Bull. 2013;36(8):1348-55. doi: 10.1248/bpb.b13-00290. PMID: 23902978. 15: Itazawa T, Adachi Y, Ito Y, Higuchi O, Mochizuki H, Shimojo N, Inoue T. Aerosol characteristics of admixture of budesonide inhalation suspension with a beta2-agonist, procaterol. Allergol Int. 2013 Mar;62(1):131-5. doi: 10.2332/allergolint.12-OA-0482. Epub 2013 Jan 25. PMID: 23348859. 16: Ohbayashi H, Adachi M. Pretreatment with inhaled procaterol improves symptoms of dyspnea and quality of life in patients with severe COPD. Int J Gen Med. 2012;5:517-24. doi: 10.2147/IJGM.S20833. Epub 2012 Jun 15. PMID: 22807639; PMCID: PMC3396116. 17: Satake M, Takahashi H, Sugawara K, Kawagoshi A, Tamaki A, Homma M, Morita R, Sato K, Sano M, Shioya T. Inhibitory effect of procaterol on exercise dynamic lung hyperinflation during the 6-min walk test in stable patients with chronic obstructive pulmonary disease. Arzneimittelforschung. 2011;61(1):8-13. doi: 10.1055/s-0031-1296162. PMID: 21355441. 18: Kobayashi H, Masuda M, Kashiyama E, Koga N, Yasuda Y, Shibutani T, Endo K, Funaki T, Miyamoto T. Pharmacokinetic study of the oral administration of procaterol hydrochloride hydrate 50 µg in healthy adult Japanese men. Int J Clin Pharmacol Ther. 2010 Nov;48(11):744-50. doi: 10.5414/cpp48744. PMID: 20979933. 19: Asano K, Yamada-Yamasawa W, Kudoh H, Matsuzaki T, Nakajima T, Hakuno H, Hiraoka R, Fukunaga K, Oguma T, Sayama K, Yamaguchi K, Nagabukuro A, Harada Y, Ishizaka A. Association between beta-adrenoceptor gene polymorphisms and relative response to beta 2-agonists and anticholinergic drugs in Japanese asthmatic patients. Respirology. 2010 Jul;15(5):849-54. doi: 10.1111/j.1440-1843.2010.01786.x. Epub 2010 Jun 9. PMID: 20546196. 20: Li G, Nan H, Zheng X. The investigation of photo-induced chemiluminescence on Co2+-doped TiO2 nanoparticles and its analytical application. Analyst. 2009 Jul;134(7):1396-404. doi: 10.1039/b816226c. Epub 2009 Mar 25. PMID: 19562208.

View History

Dezocine HBr

Dezocine HBr