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MedKoo Cat#: 526053 | Name: Procaterol free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Procaterol is an intermediate-acting β2 adrenoreceptor agonist used for the treatment of asthma. Procaterol demonstrated interaction patterns with the CHK1 active site similar to CHK1 inhibitor (CCT245737).

Chemical Structure

Procaterol free base
Procaterol free base
CAS#72332-33-3 (free base)

Theoretical Analysis

MedKoo Cat#: 526053

Name: Procaterol free base

CAS#: 72332-33-3 (free base)

Chemical Formula: C16H22N2O3

Exact Mass: 290.1630

Molecular Weight: 290.36

Elemental Analysis: C, 66.18; H, 7.64; N, 9.65; O, 16.53

Price and Availability

Size Price Availability Quantity
100mg USD 950.00
200mg USD 1,750.00
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Related CAS #
59828-07-8 (HCl) 62929-91-3 (HCl) 72332-33-3 (free base) 81262-93-3 (HCl hemihydrate)
Synonym
Procaterol; OPC 2009; OPC-2009; OPC2009; CI 888; CI-888; CI888.
IUPAC/Chemical Name
8-hydroxy-5-((1R,2S)-1-hydroxy-2-(isopropylamino)butyl)quinolin-2(1H)-one
InChi Key
FKNXQNWAXFXVNW-BLLLJJGKSA-N
InChi Code
InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)/t12-,16+/m0/s1
SMILES Code
O=C1NC2=C(C([C@@H](O)[C@@H](NC(C)C)CC)=CC=C2O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Procaterol is an intermediate-acting β2 adrenoreceptor agonist used for the treatment of asthma.
In vitro activity:
This study evaluated procaterol and dexamethasone in the hydrogen peroxide (H2O2)-induced immortal human bronchial epithelial cell model of oxidative stress and investigated the underlying mechanisms. Results showed that exposure to 125 μM H2O2 for 2 h led to a 50% reduction in the cell viability, significantly increased the percentage of apoptosis, and elevated levels of malondialdehyde and reactive oxygen species. Pretreatment with procaterol (25 - 200 nM) could reduce these effects in a dose-dependent manner. In contrast, pretreatment with dexamethasone (100 nM, 1000 nM) was inefficient. Reference: J Pharmacol Sci. 2014;125(1):39-50. https://pubmed.ncbi.nlm.nih.gov/24739282/
In vivo activity:
Three intervention groups were investigated: a procaterol inhalation only group; a procaterol inhalation plus endotoxin injection mouse group (in vivo); and a procaterol incubation group (in vitro). The diaphragm muscle in all groups was dissected and measurements of its contractile properties were performed. The effects of procaterol inhalation shifted the force-frequency curves upward at 30 minutes after inhalation, and inhibited the decline of force-frequency curves due to endotoxin injection in vivo. Reference: Allergol Int. 2007 Sep;56(3):285-91. https://pubmed.ncbi.nlm.nih.gov/17646734/

Preparing Stock Solutions

The following data is based on the product molecular weight 290.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Deng Z, Zhou JJ, Sun SY, Zhao X, Sun Y, Pu XP. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. doi: 10.1254/jphs.13206fp. Epub 2014 Apr 16. PMID: 24739282. 2. Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuda H, Deng X, Sasaki T, Kubo H, Nagatomi R. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. doi: 10.1016/j.ejphar.2010.09.056. Epub 2010 Oct 15. PMID: 20940011. 3. Shindoh C, Sasaki K, Shindoh Y, Tamura G. Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. doi: 10.2332/allergolint.O-06-463. Epub 2007 Aug 1. PMID: 17646734. 4. Tashimo H, Yamashita N, Ishida H, Nagase H, Adachi T, Nakano J, Yamamura K, Yano T, Yoshihara H, Ohta K. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. doi: 10.2332/allergolint.O-06-456. Epub 2007 Jul 1. PMID: 17582211.
In vitro protocol:
1. Deng Z, Zhou JJ, Sun SY, Zhao X, Sun Y, Pu XP. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. doi: 10.1254/jphs.13206fp. Epub 2014 Apr 16. PMID: 24739282. 2. Yamaya M, Nishimura H, Hatachi Y, Yoshida M, Fujiwara H, Asada M, Nakayama K, Yasuda H, Deng X, Sasaki T, Kubo H, Nagatomi R. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. doi: 10.1016/j.ejphar.2010.09.056. Epub 2010 Oct 15. PMID: 20940011.
In vivo protocol:
1. Shindoh C, Sasaki K, Shindoh Y, Tamura G. Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. doi: 10.2332/allergolint.O-06-463. Epub 2007 Aug 1. PMID: 17646734. 2. Tashimo H, Yamashita N, Ishida H, Nagase H, Adachi T, Nakano J, Yamamura K, Yano T, Yoshihara H, Ohta K. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. doi: 10.2332/allergolint.O-06-456. Epub 2007 Jul 1. PMID: 17582211.
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message Sent On: Fri Aug 30 11:22:02 2024 Search: Procaterol From: evan.izzo@medkoo.com 20 selected items PubMed Results Items 1-20 of 20 (Display the 20 citations in PubMed) 1: Tang B, Zhang H, Zhang Z, Di B, Su M. Determination of 13 potential anti- obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS. J Pharm Biomed Anal. 2024 Aug 15;246:116236. doi: 10.1016/j.jpba.2024.116236. Epub 2024 May 19. PMID: 38772203. 2: Kawaguchi K, Yokoyama S, Wang H, Asano S. Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia. Biochem Biophys Res Commun. 2024 Apr 9;703:149685. doi: 10.1016/j.bbrc.2024.149685. Epub 2024 Feb 13. PMID: 38373381. 3: Giridhara Prema S, Chandrasekaran J, Kanekar S, George M, Prasad TSK, Raju R, Dagamajalu S, Balaya RDA. Cisplatin and Procaterol Combination in Gastric Cancer? Targeting Checkpoint Kinase 1 for Cancer Drug Discovery and Repurposing by an Integrated Computational and Experimental Approach. OMICS. 2024 Jan;28(1):8-23. doi: 10.1089/omi.2023.0163. Epub 2024 Jan 8. PMID: 38190280. 4: Zhang Z, Cai Q, Wang J, Yao Z, Ji F, Hang Y, Ma J, Jiang H, Yan B, Zhanghuang C. Development and validation of a nomogram to predict cancer-specific survival in nonsurgically treated elderly patients with prostate cancer. Sci Rep. 2023 Oct 18;13(1):17719. doi: 10.1038/s41598-023-44911-z. PMID: 37853026; PMCID: PMC10584808. 5: Chen Q, Zhang Y, Sun C, Liu L, Luo X, Wang H, Ni S. Corrigendum: Case report: deterioration of infantile hemangioma related to oral or nebulized administration of β2-AR agonist: three cases reports. Front Oncol. 2023 Sep 8;13:1282607. doi: 10.3389/fonc.2023.1282607. Erratum for: Front Oncol. 2022 Nov 10;12:1000099. doi: 10.3389/fonc.2022.1000099. PMID: 37746293; PMCID: PMC10515650. 6: Liu X, Dong Y, Lv W. Value exploration of treating pediatric pneumonia with ambroxol hydrochloride and procaterol hydrochloride. Minerva Pediatr (Torino). 2024 Feb;76(1):145-147. doi: 10.23736/S2724-5276.23.07341-X. Epub 2023 Jun 16. PMID: 37335187. 7: Wu S, Ootawa T, Sekio R, Smith H, Islam MZ, Uno Y, Shiraishi M, Miyamoto A. Involvement of beta3-adrenergic receptors in relaxation mediated by nitric oxide in chicken basilar artery. Poult Sci. 2023 Jun;102(6):102633. doi: 10.1016/j.psj.2023.102633. Epub 2023 Mar 8. PMID: 37001317; PMCID: PMC10070147. 8: Wang YR, Cheng DQ, Ma L, Liu X. [β-arrestin2 recruitment by β-adrenergic receptor agonists and antagonists]. Sheng Li Xue Bao. 2022 Dec 25;74(6):993-1004. Chinese. PMID: 36594387. 9: Chen A, Wu W, Lin S, Xie L. Bioinformatic Exploration of Hub Genes and Potential Therapeutic Drugs for Endothelial Dysfunction in Hypoxic Pulmonary Hypertension. Comput Math Methods Med. 2022 Nov 28;2022:3677532. doi: 10.1155/2022/3677532. PMID: 36483920; PMCID: PMC9723419. 10: Chen Q, Zhang Y, Sun C, Liu L, Luo X, Wang H, Ni S. Case report: Deterioration of infantile hemangioma related to oral or nebulized administration of β2-AR agonist: Three cases reports. Front Oncol. 2022 Nov 10;12:1000099. doi: 10.3389/fonc.2022.1000099. Erratum in: Front Oncol. 2023 Sep 08;13:1282607. doi: 10.3389/fonc.2023.1282607. PMID: 36439407; PMCID: PMC9691007. 11: Xi J, Talaat M, Si XA. Two-way coupling and Kolmogorov scales on inhaler spray plume evolutions from Ventolin, ProAir, and Qvar. Math Biosci Eng. 2022 Aug 1;19(11):10915-10940. doi: 10.3934/mbe.2022510. PMID: 36124575. 12: Behrsing HP, Wahab A, Ukishima L, Grodi C, Frentzel S, Johne S, Ishikawa S, Ito S, Wieczorek R, Budde J, Keyser BM, Haswell LE, Thorne D, Bishop E, Breheny D, Cao X, Qin Q, Patel V. Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance. Altern Lab Anim. 2022 Jul;50(4):293-309. doi: 10.1177/02611929221114383. Epub 2022 Aug 7. PMID: 35938181. 13: Brucker BM, King J, Mudd PN Jr, McHale K. Selectivity and Maximum Response of Vibegron and Mirabegron for β3-Adrenergic Receptors. Curr Ther Res Clin Exp. 2022 May 14;96:100674. doi: 10.1016/j.curtheres.2022.100674. PMID: 35693456; PMCID: PMC9184556. 14: Kawaguchi K, Nakayama S, Saito D, Kogiso H, Yasuoka K, Marunaka Y, Nakahari T, Asano S. Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia. J Cell Sci. 2022 Mar 15;135(6):jcs259201. doi: 10.1242/jcs.259201. Epub 2022 Mar 16. PMID: 35132996. 15: Hanibuchi M, Mitsuhashi A, Kajimoto T, Saijo A, Kitagawa T. A case of chest tightness variant asthma : the usefulness of fractional exhaled nitric oxide as a marker for the diagnosis and clinical improvement. J Med Invest. 2021;68(3.4):389-392. doi: 10.2152/jmi.68.389. PMID: 34759166. 16: Sato K, Iwata A, Kurihara M, Mano T, Toda T. Stress cardiomyopathy (Takotsubo syndrome) in patients who received adrenergic agonist drugs: A pharmacovigilance study using the Japanese Adverse Drug Event Report (JADER) database. J Cardiol. 2022 Jan;79(1):36-41. doi: 10.1016/j.jjcc.2021.08.019. Epub 2021 Sep 4. PMID: 34493421. 17: Miranda M, Avila I, Esparza J, Shwartz Y, Hsu YC, Berdeaux R, Lowry WE. Defining a Role for G-Protein Coupled Receptor/cAMP/CRE-Binding Protein Signaling in Hair Follicle Stem Cell Activation. J Invest Dermatol. 2022 Jan;142(1):53-64.e3. doi: 10.1016/j.jid.2021.05.031. Epub 2021 Jul 17. PMID: 34280464; PMCID: PMC8989631. 18: Muramatsu H, Kuriyama A. Wheezing of unexpected etiology: A case report of pea aspiration mimicking bronchus obstruction caused by a tumor. Ann Med Surg (Lond). 2021 Jan 22;62:265-268. doi: 10.1016/j.amsu.2021.01.064. PMID: 33537141; PMCID: PMC7841212. 19: Liu H, Shin SH, Chen H, Liu T, Li Z, Hu Y, Liu F, Zhang C, Kim DJ, Liu K, Dong Z. CDK12 and PAK2 as novel therapeutic targets for human gastric cancer. Theranostics. 2020 May 15;10(14):6201-6215. doi: 10.7150/thno.46137. PMID: 32483448; PMCID: PMC7255043. 20: Ito K, Kanemitsu Y, Fukumitsu K, Inoue Y, Nishiyama H, Yamamoto S, Kitamura Y, Kurokawa R, Takeda N, Fukuda S, Uemura T, Tajiri T, Takakuwa O, Ohkubo H, Takemura M, Maeno K, Ito Y, Oguri T, Niimi A. The impact of budesonide inhalation suspension for asthma hospitalization: In terms of length of stay, recovery time from symptoms, and hospitalization costs. Allergol Int. 2020 Oct;69(4):571-577. doi: 10.1016/j.alit.2020.04.003. Epub 2020 May 13. PMID: 32417100.