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MedKoo Cat#: 317598 | Name: Dezocine HBr

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dezocine (Dalgan, WY16225) is an opioid analgesic. First synthesized in 1970, it acts at mu-, delta-, and kappa-opioid receptors. Dezocine acts as a mixed agonist/antagonist of opioid receptors. It is related to other benzomorphans such as pentazocine, with a similar profile of effects that include analgesic action and euphoria. Unlike many other benzomorphans however, it is a silent antagonist of the κ-opioid receptor, and in accordance, does not produce side effects such as dysphoria or hallucinations at any dose.

Chemical Structure

Dezocine HBr
Dezocine HBr
CAS#57236-36-9 (HBr)

Theoretical Analysis

MedKoo Cat#: 317598

Name: Dezocine HBr

CAS#: 57236-36-9 (HBr)

Chemical Formula: C16H24BrNO

Exact Mass: 245.1780

Molecular Weight: 326.28

Elemental Analysis: C, 58.90; H, 7.41; Br, 24.49; N, 4.29; O, 4.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
53648-55-8 (free base) 57236-36-9 (HBr)
Synonym
DEZOCINE; Dalgan; Wy-16225; Wy 16225; Wy16225; CHEMBL1685; Dezocina; Dezocinum; Dezocine hydrobromide, Dezocine monohydrobromide; MCV 4206; NIH 8834; UM 972.
IUPAC/Chemical Name
(5R,11S,13S)-13-amino-5-methyl-5,6,7,8,9,10,11,12-octahydro-5,11-methanobenzo[10]annulen-3-ol hydrobromide
InChi Key
HLYQVVMHTCPUKR-RXAPEJBRSA-N
InChi Code
InChI=1S/C16H23NO.BrH/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16;/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3;1H/t12-,15-,16+;/m0./s1
SMILES Code
OC1=CC([C@@]([C@H]2N)(C)CCCCC[C@@]2([H])C3)=C3C=C1.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 326.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bian X, Zhou R, Yang Y, Li P, Hang Y, Hu Y, Yang L, Wen D. Divergent Effect of Dezocine, Morphine and Sufentanil on Intestinal Motor Function in Rats. Int J Med Sci. 2015 Oct 15;12(11):848-52. doi: 10.7150/ijms.12616. eCollection 2015. PubMed PMID: 26640403; PubMed Central PMCID: PMC4643074. 2: Chen XK, Zhou YP, Zhang X, Xia LP, Li AF, Liu H, Yu HQ. Conscious sedation with midazolam and dezocine for diagnostic flexible bronchoscopy. Eur Rev Med Pharmacol Sci. 2015 Oct;19(19):3688-92. PubMed PMID: 26502859. 3: Zhou X, Zhang C, Wang M, Yu L, Yan M. Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015 Aug 19;10(8):e0136091. doi: 10.1371/journal.pone.0136091. eCollection 2015. PubMed PMID: 26287536; PubMed Central PMCID: PMC4545891. 4: Yu F, Zhou J, Xia S, Xu H, Wang X. Dezocine Prevents Postoperative Hyperalgesia in Patients Undergoing Open Abdominal Surgery. Evid Based Complement Alternat Med. 2015;2015:946194. doi: 10.1155/2015/946194. Epub 2015 Jun 11. PubMed PMID: 26170890; PubMed Central PMCID: PMC4480811. 5: Xu Y, Zhu Y, Wang S, Ren Y, Miao C. Dezocine attenuates fentanyl-induced cough in a dose-dependent manner-a randomized controlled trial. Int J Clin Exp Med. 2015 Apr 15;8(4):6091-6. eCollection 2015. PubMed PMID: 26131209; PubMed Central PMCID: PMC4483907. 6: Ren BX, Zong J, Tang JC, Sun DP, Hui X, Li RQ, Zhang JL, Ji Y. Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients. Genet Mol Res. 2015 May 25;14(2):5571-6. doi: 10.4238/2015.May.25.8. PubMed PMID: 26125754. 7: Li S, Min S, Wu B, Tang W. [Application of patient-controlled intravenous analgesia of dezocine combined with sufentanil in burn patients after surgery]. Zhonghua Shao Shang Za Zhi. 2015 Feb;31(1):48-51. Chinese. PubMed PMID: 25876640. 8: Zheng M, Guo Y, Shan S, Yang S. Dezocine for anesthesia and stress reduction in induced abortion. Patient Prefer Adherence. 2015 Mar 3;9:369-72. doi: 10.2147/PPA.S76507. eCollection 2015. PubMed PMID: 25784792; PubMed Central PMCID: PMC4356682. 9: Li X, Xia Q, Li W. Comparison of the effects of dezocine, fentanyl, and placebo on emergence agitation after sevoflurane anesthesia in children. Int J Clin Pharmacol Ther. 2015 Mar;53(3):241-6. doi: 10.5414/CP202184. PubMed PMID: 25669611. 10: Su Z, Zhang Y, Liu Y, An LJ, Liu HL. [The effect of dezocine in prevention of adverse reaction of tracheal extubation in nasal endoscopic operation]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2014 Sep;30(5):394-5, 400. Chinese. PubMed PMID: 25571627.