Glycodiazine | CAS#339-44-6

MedKoo Cat#: 317978 | Name: Glycodiazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glycodiazine is a sulfapyrimidine derivative with antihyperglycemic activity. Like sulfonylureas, glymidine is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells and increasing the sensitivity of peripheral tissues to insulin. Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane.

Chemical Structure

Glycodiazine

CAS#339-44-6 (free acid)

Theoretical Analysis

MedKoo Cat#: 317978

Name: Glycodiazine

CAS#: 339-44-6 (free acid)

Chemical Formula: C13H15N3O4S

Exact Mass: 309.0783

Molecular Weight: 309.34

Elemental Analysis: C, 50.47; H, 4.89; N, 13.58; O, 20.69; S, 10.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

339-44-6 (free acid) 3459-20-9 (sodium)

Synonym

Glycodiazine; GLYMIDINE; Glycodiazine; Glidiazine; Glycodiazin; Glymidinum; Glycodiazin [German];

IUPAC/Chemical Name

N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide

InChi Key

QFWPJPIVLCBXFJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H15N3O4S/c1-19-7-8-20-11-9-14-13(15-10-11)16-21(17,18)12-5-3-2-4-6-12/h2-6,9-10H,7-8H2,1H3,(H,14,15,16)

SMILES Code

COCCOC1=CN=C(N=C1)NS(=O)(=O)C2=CC=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 309.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ullrich KJ, Rumrich G, Baumann K. Renal proximal tubular buffer-(glycodiazine) transport. Inhomogeneity of local transport rate, dependence on sodium, effect of inhibitors and chronic adaptation. Pflugers Arch. 1975 Jun 26;357(3-4):149-63. PubMed PMID: 127986. 2: Ghanem MH, Guirgis FK. Effect of insulin and glycodiazine on the level of plasma free fatty acids in bilharzial (schistosomal) hepatic fibrosis. J Trop Med Hyg. 1972 Jun;75(6):115-8. PubMed PMID: 5044326. 3: Matsuno Z. [Histological studies on the pancreatic islets of Langerhans of rabbits after long-term glycodiazine administration]. Nihon Naibunpi Gakkai Zasshi. 1971 Jun 20;47(3):165-73. Japanese. PubMed PMID: 4934487. 4: Cheah JS, Tan BY. Evaluation of glycodiazine (Lycanol) in the treatment of diabetes mellitus. Singapore Med J. 1970 Jun;11(2):91-5. PubMed PMID: 5505890. 5: Chugh RN, Bahl AL, Bhalla AS, Mathur KP. Trial of a new antidiabetic compound (glycodiazine) in diabetes mellitus. J Indian Med Assoc. 1970 Jan 16;54(2):62-5. PubMed PMID: 5418147. 6: Choi Y, Kreines K. Effect of glycodiazine on blood sugar in diabetes mellitus. Diabetes. 1968 Aug;17(8):509-12. PubMed PMID: 4875654. 7: Chhetri MK, Pal K. Treatment of diabetes mellitus with glycodiazine. J Indian Med Assoc. 1968 May 16;50(10):476-81. PubMed PMID: 5704866. 8: Camponovo LE, Maggi N. [On the pharmacology of the blood sugar decreasing substance Glycodiazine]. Arzneimittelforschung. 1968 May;18(5):577-80. German. PubMed PMID: 5755885. 9: [Current data on the action of glycodiazine]. Journ Annu Diabetol Hotel Dieu. 1968;9:433-7. French. PubMed PMID: 5748225. 10: Warembourg H, Jaillard J. [Experimentation with glycodiazine in the treatment of diabetes. Apropos of 30 cases]. Lille Med. 1967 May;12(4):Suppl:516-9. French. PubMed PMID: 5619705. 11: Janin J, Coing F, Cholat P, Bertrand JL, Potton F. [Oral therapy of diabetes mellitus with glycodiazine. (Experimentation on 54 cases)]. Rev Lyon Med. 1967 Apr 30;16(8):333-40. French. PubMed PMID: 5607794. 12: Zavala A, Martí ML, Ruiz M, Busquet JC. [Clinical experience with glycodiazine (Sh 717)]. Prensa Med Argent. 1967 Apr 14;54(7):313-5. Spanish. PubMed PMID: 5614086. 13: Liberti R, Cicconetti C. [Oral therapy of diabetes mellitus with SH 717. Glycodiazine or gondafon]. Minerva Med. 1967 Mar 21;58(23):978-87. Italian. PubMed PMID: 6023633. 14: Thäle E. [Indication for the use of glycodiazine (Redul) as an oral antidiabetic]. Med Welt. 1967 Feb 18;7:392-4. German. PubMed PMID: 6045243. 15: Scheiffarth F, Weist F, Warnatz H, Schnell K. [The presence of insulin antibodies and the influence on insulin-protein binding of sulfonylurea and glycodiazine]. Med Pharmacol Exp Int J Exp Med. 1967;17(1):17-24. German. PubMed PMID: 6072678. 16: Eisenberg S, Cohen AM. Clinical trial of glycodiazine--a new oral hypoglycemic drug. Isr J Med Sci. 1966 Nov-Dec;2(6):768-73. PubMed PMID: 5334155. 17: Camponovo LE, Maggi ND. [Pharmacologic study of a new hypoglycemic: glycodiazine]. Prensa Med Argent. 1966 Aug 26;53(34):1857-62. Spanish. PubMed PMID: 5998759. 18: Wasty SS, Hazell K. The value of glycodiazine ('Gondafon') for the elderly diabetic. Br J Clin Pract. 1966 Aug;20(8):413-5. PubMed PMID: 5944031. 19: Moritz V, Häwert D. [Studies with glycodiazine on the islands of Langerhans of inbred white mice]. Arzneimittelforschung. 1966 Apr;16(4):566-8. German. PubMed PMID: 4863900. 20: Gerhards E, Kolb KH. [2-Benzolsulfonamido-5(beta-methoxy-ethoxy)-pyrimidine (Glycodiazine). II. Metabolism of 2-benzolsulfonamido-5(beta-hydroxy-ethoxy)-pyrimidine, a blood sugar reducing metabolite of glycodiazine in man]. Arzneimittelforschung. 1965 Dec;15(12):1375-9. German. PubMed PMID: 5899812.