Glymidine sodium | CAS#3459-20-9 | sulfonamide hypoglycemic agent

MedKoo Cat#: 530260 | Name: Glymidine sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.

Chemical Structure

Glymidine sodium

CAS#3459-20-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 530260

Name: Glymidine sodium

CAS#: 3459-20-9 (sodium)

Chemical Formula: C13H14N3NaO4S

Exact Mass: 331.0603

Molecular Weight: 331.32

Elemental Analysis: C, 47.13; H, 4.26; N, 12.68; Na, 6.94; O, 19.32; S, 9.68

Price and Availability

Size	Price	Availability
5mg	USD 110.00	Ready to ship
10mg	USD 180.00	Ready to ship
25mg	USD 385.00	Ready to ship
50mg	USD 685.00	Ready to ship
100mg	USD 1,250.00	Ready to ship
200mg	USD 2,250.00	Ready to ship

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Related CAS #

339-44-6 (free acid) 3459-20-9 (sodium)

Synonym

BS 717; Glycanol; Glycodiazin; Glycodiazine; Glycodiazine sodium; Glyconormal; Glymidine; Glymidine sodium; Glymidine sodium salt; Gondafon; Lycanol; Redul; Redul IF; Redul sodium; SH 717;

IUPAC/Chemical Name

Benzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-, sodium salt

InChi Key

NUQDEHHKOXSIEA-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H14N3O4S.Na/c1-19-7-8-20-11-9-14-13(15-10-11)16-21(17,18)12-5-3-2-4-6-12;/h2-6,9-10H,7-8H2,1H3;/q-1;+1

SMILES Code

O=S(C1=CC=CC=C1)([N-]C2=NC=C(OCCOC)C=N2)=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot# B21B11C29

QC Data

View QC data: current batch, Lot# B21B11C29

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

Glymidine sodium is an active antidiabetic that inhibits the glucose formation and supresses the elevated pyruvate oxidation, which results from the inhibition of endogenous lipid mobilization.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	125.0	377.28

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 331.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Hardison WG, Wood CA. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol. 1978 Aug;235(2):E158-64. PubMed PMID: 150796. 2: Losert W, Loge O, Jahn P. [Comparison of the beta-cytotropic effect of glymidine sodium (glycodiazine), glucagon, and isopropylnoradrenaline in rats]. Arzneimittelforschung. 1973 Sep;23(9):1251-60. German. PubMed PMID: 4149442. 3: Loge O, Losert W, Jahn P. [Influence on serum insulin concentration of sodium glymidine (glykodiazine), isopropylnorepinephrine, glucagon and theophylline in Chinese hamsters with spontaneous or streptozotocin-induced diabetes mellitus]. Res Exp Med (Berl). 1973 Jun 19;160(4):292-306. German. PubMed PMID: 4269691. 4: Losert W, Rosenthal K, Jahn P, Sitt R. [Comparative studies on the effect of sodium glymidine, glucagon and isopropylnoradrenaline on insulin secretion in rats]. Naunyn Schmiedebergs Arch Pharmakol. 1970;266(4):397-8. German. PubMed PMID: 4397505.