SC99 | CAS: 882290-02-0 | JAK2-STAT3 Inhibitor

MedKoo Cat#: 564038 | Name: SC99

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1.

Chemical Structure

SC99

CAS#882290-02-0

Theoretical Analysis

MedKoo Cat#: 564038

Name: SC99

CAS#: 882290-02-0

Chemical Formula: C15H8Cl2FN3O

Exact Mass: 335.0028

Molecular Weight: 336.15

Elemental Analysis: C, 53.60; H, 2.40; Cl, 21.09; F, 5.65; N, 12.50; O, 4.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SC99; SC-99; SC 99

IUPAC/Chemical Name

2-(2-(3-Chloro-4-fluorophenyl)hydrazono)-3-(4-chlorophenyl)-3-oxo-propanenitrile

InChi Key

ZKULFSMYRSFHKE-KGENOOAVSA-N

InChi Code

InChI=1S/C15H8Cl2FN3O/c16-10-3-1-9(2-4-10)15(22)14(8-19)21-20-11-5-6-13(18)12(17)7-11/h1-7,20H/b21-14+

SMILES Code

N#C/C(C(C1=CC=C(Cl)C=C1)=O)=N\NC2=CC=C(F)C(Cl)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ding Y, Qian J, Li H, Shen H, Li X, Kong Y, Xu Z, Chen G. Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway. Neurosci Res. 2018 May 12. pii: S0168-0102(17)30594-1. doi: 10.1016/j.neures.2018.05.002. [Epub ahead of print] PubMed PMID: 29763638. 2: Xu Z, Xu YJ, Hao YN, Ren LJ, Zhang ZB, Xu X, Cao BY, Dai KS, Zhu L, Fang Q, Kong Y, Mao XL. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659. doi: 10.1038/aps.2016.155. Epub 2017 Mar 6. PubMed PMID: 28260800; PubMed Central PMCID: PMC5457693. 3: Zhang Z, Mao H, Du X, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang X, Qiao C, Mao X. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308. doi: 10.18632/oncotarget.6974. Erratum in: Oncotarget. 2016 Dec 6;7(49):81972. PubMed PMID: 26814430; PubMed Central PMCID: PMC4891041.