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MedKoo Cat#: 318069 | Name: Isoetharine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoetharine is a selective beta2-adrenergic receptor agonist. It is used as a bronchodilator for emphysema, bronchitis and asthma.

Chemical Structure

Isoetharine
Isoetharine
CAS#530-08-5 (free base)

Theoretical Analysis

MedKoo Cat#: 318069

Name: Isoetharine

CAS#: 530-08-5 (free base)

Chemical Formula: C13H21NO3

Exact Mass: 239.1521

Molecular Weight: 239.31

Elemental Analysis: C, 65.25; H, 8.84; N, 5.85; O, 20.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
7279-75-6 (mesylate) 530-08-5 (free base)
Synonym
Isoetharine, Isoetarine, Bronkosol, Bronkometer, Etyprenalinum
IUPAC/Chemical Name
4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol
InChi Key
HUYWAWARQUIQLE-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3
SMILES Code
OC1=CC=C(C(O)C(NC(C)C)CC)C=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 239.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shrestha M, Gourlay S, Robertson S, Bidadi K, Wainscott M, Hayes J. Isoetharine versus albuterol for acute asthma: greater immediate effect, but more side effects. Am J Med. 1996 Mar;100(3):323-7. PubMed PMID: 8629678. 2: Emerman CL, Cydulka RK, Effron D, Lukens TW, Gershman H, Boehm SP. A randomized, controlled comparison of isoetharine and albuterol in the treatment of acute asthma. Ann Emerg Med. 1991 Oct;20(10):1090-3. PubMed PMID: 1928879. 3: Lew DB, Herrod HG, Crawford LV. Combination of atropine and isoetharine aerosol therapy in pediatric acute asthma. Ann Allergy. 1990 Feb;64(2 Pt 2):195-200. PubMed PMID: 2301781. 4: Casthely PA, Cottrell JE, Urquhart PA. Comparison of metaproterenol, isoetharine and salbutamol in the relief of methacholine-induced bronchospasm in dogs. Can Anaesth Soc J. 1985 Mar;32(2):112-8. PubMed PMID: 3886091. 5: Koepke JW, Christopher KL, Chai H, Selner JC. Dose-dependent bronchospasm from sulfites in isoetharine. JAMA. 1984 Jun 8;251(22):2982-3. PubMed PMID: 6716626. 6: Peerless AG, Rachelefsky GS, Mickey MR, Katz RM, Siegel SC. Bronchodilator characteristics of nebulized metaproterenol sulfate, isoetharine, and atropine in chronic asthma. J Allergy Clin Immunol. 1983 Dec;72(6):702-8. PubMed PMID: 6358329. 7: König P, Hurst DJ. Nebulized isoetharine and fenoterol in acute attacks of asthma. Arch Intern Med. 1983 Jul;143(7):1361-4. PubMed PMID: 6347110. 8: Spellman GG Jr, Gruebel BJ, Epstein JD, Rotman HH, Weg JG. Comparison of fenoterol, isoproterenol, and isoetharine with phenylephrine aerosol in asthma. J Clin Pharmacol. 1983 Feb-Mar;23(2-3):82-8. PubMed PMID: 6853746. 9: Twarog FJ, Leung DY. Anaphylaxis to a component of isoetharine (sodium bisulfite). JAMA. 1982 Oct 22;248(16):2030-1. PubMed PMID: 7120631. 10: Yates T, Dubin B, Bell-Jesion C. A comparison of isoetharine and albuterol: report of changes in pulmonary functions over 1 hour. J Am Osteopath Assoc. 1982 Apr;81(8):546-8. PubMed PMID: 7042663. 11: Sinha BN, Allan GW, Lees AW. Oral orciprenaline, salbutamol and isoetharine compared. Br J Dis Chest. 1973 Jan;67(1):61-5. PubMed PMID: 4143896. 12: Strunge B. [Sustained-release isoetharine. The bronchodilating effect compared with orciprenaline and placebos in a double-blind study]. Ugeskr Laeger. 1972 Jul 3;134(27):1432-4. Danish. PubMed PMID: 4562049. 13: Jensen V. [Bronchodilator effect of oral isoetharine and isoprenaline inhalation]. Nord Med. 1971 Jun 17;85(24):745-8. Danish. PubMed PMID: 4933262. 14: Jensen V. [Broncholytic effect of isoetharine per os and inhalation of isoprenaline]. Nord Med. 1971 Jun 10;85(23):728. Norwegian. PubMed PMID: 5089019. 15: Chapman TT, De Wytt C. Isoetharine and salbutamol--a comparative bronchodilator trial. J Ir Med Assoc. 1971 Mar 4;64(407):137-40. PubMed PMID: 4932017. 16: Thiringer G, Bergh NP, Svedmyr N. A comparative study of the effects of isoetharine and some other adrenergic beta-stimulators in chronic obstructive lung disease. Scand J Respir Dis. 1971;52(4):183-91. PubMed PMID: 5161421. 17: Howard LA, Coleman M. A crossover comparison of isoproterenol, metaproterenol and isoetharine by spirometric determinations. Ann Allergy. 1967 Sep;25(9):512-9. PubMed PMID: 4861327. 18: Unger DL, Unger L. Isoetharine methanesulfonate with phenylephrine hydrochloride and thenyldiamine (Bronkometer) in hypertensive and sympathomimetic amine-sensitive asthmatic patients. Dis Chest. 1967 Feb;51(2):153-5. PubMed PMID: 4381226. 19: LANDS AM. Absorption profile of the bronchodilator drug, isoetharine. Arch Int Pharmacodyn Ther. 1962 Aug 1;138:462-72. PubMed PMID: 13928488. 20: LANDS AM, LUDUENA FP, HOPPE JO, OYEN IH. The pharmacologic actions of the bronchodilator drug, isoetharine. J Am Pharm Assoc Am Pharm Assoc. 1958 Oct;47(10):744-8. PubMed PMID: 13587307.