Synonym
AZD8848; AZD-8848; AZD 8848; DSP-3025; DSP 3025; DSP3025.
IUPAC/Chemical Name
methyl 2-(3-(((3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl)(3-morpholinopropyl)amino)methyl)phenyl)acetate
InChi Key
FEFIBEHSXLKJGI-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H43N7O5/c1-3-4-16-41-28-32-26(30)25-27(33-28)36(29(38)31-25)13-7-12-35(11-6-10-34-14-17-40-18-15-34)21-23-9-5-8-22(19-23)20-24(37)39-2/h5,8-9,19H,3-4,6-7,10-18,20-21H2,1-2H3,(H,31,38)(H2,30,32,33)
SMILES Code
O=C(OC)CC1=CC=CC(CN(CCCN2C(NC3=C(N)N=C(OCCCC)N=C23)=O)CCCN4CCOCC4)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related:
866269-28-5 (AZD8848 free base)
1162113-73-6 (AZD8848 HCl salt)
Note: Structrue was from: Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. Keith Biggadike, Mahbub Ahmed, Doug I. Ball, Diane M. Coe, Deidre A. Dalmas Wilk, Chris D. Edwards, Bob H. Gibbon, Charlotte J. Hardy, Stephen A. Hermitage, Joanne O. Hessey, Aimee E. Hillegas, Stephen C. Hughes, Linos Lazarides, Xiao Q. Lewell, Amanda Lucas, David N. Mallett, Mark A. Price, Fiona M. Priest, Diana J. Quint, Poonam Shah, Anesh Sitaram, Stephen A. Smith, Richard Stocker, Naimisha A. Trivedi, Daphne C. Tsitoura, and Victoria Weller Publication Date (Web): February 10, 2016 (Drug Annotation). DOI: 10.1021/acs.jmedchem.5b01647
Preparing Stock Solutions
The following data is based on the
product
molecular weight
569.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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