Ketohypoglycin | CAS#5746-24-7 | Methylenecyclopropylpyruvate

MedKoo Cat#: 558373 | Name: Ketohypoglycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ketohypoglycin has been used to study the inhibition of gluconeogenesis in isolated rat liver cells.

Chemical Structure

Ketohypoglycin

CAS#5746-24-7

Theoretical Analysis

MedKoo Cat#: 558373

Name: Ketohypoglycin

CAS#: 5746-24-7

Chemical Formula: C7H8O3

Exact Mass: 140.0500

Molecular Weight: 140.14

Elemental Analysis: C, 60.00; H, 5.75; O, 34.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ketohypoglycin; Methylenecyclopropylpyruvate;

IUPAC/Chemical Name

2-Methylene-alpha-oxocyclopropanepropanoic acid

InChi Key

IKTGVEIOCJLOFU-UHFFFAOYSA-N

InChi Code

InChI=1S/C7H8O3/c1-4-2-5(4)3-6(8)7(9)10/h5H,1-3H2,(H,9,10)

SMILES Code

O=C(O)C(CC1C(C1)=C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 140.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kean EA, Pogson CI. Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Biochem J. 1979 Sep 15;182(3):789-96. PubMed PMID: 518564; PubMed Central PMCID: PMC1161413. 2: Marusich JA, Grant KR, Blough BE, Wiley JL. Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice. Neurotoxicology. 2012 Oct;33(5):1305-13. doi: 10.1016/j.neuro.2012.08.003. Epub 2012 Aug 23. PubMed PMID: 22922498; PubMed Central PMCID: PMC3475178. 3: Kler RS, Sherratt HS, Turnbull DM. The measurement of mitochondrial beta-oxidation by release of 3H2O from [9,10-3H]hexadecanoate: application to skeletal muscle and the use of inhibitors as models of metabolic disease. Biochem Med Metab Biol. 1992 Apr;47(2):145-56. PubMed PMID: 1515172. 4: Billington D, Sherratt HS. Hypoglycin and metabolically related inhibitors. Methods Enzymol. 1981;72:610-6. PubMed PMID: 7311858.