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MedKoo Cat#: 126144 | Name: Ulodesine succinate anhydrous

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily oral, chronic treatment for gout. Ulodesine is currently being developed by Biocryst. Ulodesine acts upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA). Ulodesine has an IC(50) of 0.5 nM to PNP. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout.

Chemical Structure

Ulodesine succinate anhydrous
Ulodesine succinate anhydrous
CAS#1246200-39-4 (succinate)

Theoretical Analysis

MedKoo Cat#: 126144

Name: Ulodesine succinate anhydrous

CAS#: 1246200-39-4 (succinate)

Chemical Formula: C28H38N8O10

Exact Mass: 646.2711

Molecular Weight: 646.66

Elemental Analysis: C, 52.01; H, 5.92; N, 17.33; O, 24.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1246200-39-4 (succinate) 548486-59-5 (free base)
Synonym
Ulodesine succinate anhydrous; BCX4208; BCX 4208; BCX-4208; Ulodesine; DADMe-immucillin H
IUPAC/Chemical Name
7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hemisuccinate
InChi Key
YCQWGDWFVIEPBB-KAVFMPKWSA-N
InChi Code
InChI=1S/2C12H16N4O3.C4H6O4/c2*17-5-8-3-16(4-9(8)18)2-7-1-13-11-10(7)14-6-15-12(11)19;5-3(6)1-2-4(7)8/h2*1,6,8-9,13,17-18H,2-5H2,(H,14,15,19);1-2H2,(H,5,6)(H,7,8)/t2*8-,9+;/m11./s1
SMILES Code
OC(=O)CCC(O)=O.OC[C@H]1CN(CC2=CNC3=C2N=CNC3=O)C[C@@H]1O.OC[C@H]4CN(CC5=CNC6=C5N=CNC6=O)C[C@@H]4O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 646.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bantia S, Parker C, Upshaw R, Cunningham A, Kotian P, Kilpatrick JM, Morris P, Chand P, Babu YS. Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies. Int Immunopharmacol. 2010 Jul;10(7):784-90. doi: 10.1016/j.intimp.2010.04.009. Epub 2010 Apr 22. PubMed PMID: 20399911. 2: Kamath VP, Juarez-Brambila JJ, Morris PE Jr. Synthesis of labeled BCX-4208, a  potent inhibitor of purine nucleoside phosphorylase. Drug Test Anal. 2009 Mar;1(3):125-7. doi: 10.1002/dta.24. PubMed PMID: 20355185.

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Ulodesine

Ulodesine

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