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MedKoo Cat#: 317758 | Name: Drotaverine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Drotaverine Hydrochloride is an antispasmodic drug, used to enhance cervical dilation during childbirth. It is structurally related to papaverine and is a selective inhibitor of phosphodiesterase 4. Drotaverin HCl has no anticholinergic effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models.

Chemical Structure

Drotaverine HCl
Drotaverine HCl
CAS# 985-12-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 317758

Name: Drotaverine HCl

CAS#: 985-12-6 (HCl)

Chemical Formula: C24H32ClNO4

Exact Mass: 0.0000

Molecular Weight: 433.97

Elemental Analysis: C, 66.42; H, 7.43; Cl, 8.17; N, 3.23; O, 14.75

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 850.00 2 Weeks
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Related CAS #
14009-24-6 (free base) 985-12-6 (HCl)
Synonym
Drotaverine HCl; Drotaverine hydrochloride; Tetraspasmin-Lefa; No-Spa Hydrochloride
IUPAC/Chemical Name
1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline;hydrochloride
InChi Key
JBFLYOLJRKJYNV-MASIZSFYSA-N
InChi Code
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
SMILES Code
CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rai RR, Dwivedi M, Kumar N. Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: a randomized double-blind placebo-controlled study. Saudi J Gastroenterol. 2014 Nov-Dec;20(6):378-82. doi: 10.4103/1319-3767.145331. PubMed PMID: 25434320; PubMed Central PMCID: PMC4271014. 2: Narang M, Shah D, Akhtar H. Efficacy and Safety of Drotaverine Hydrochloride in Children with Recurrent Abdominal Pain: A Randomized Placebo Controlled Trial. Indian Pediatr. 2015 Oct 9;52(10):847-51. PubMed PMID: 26499007. 3: Ivshina IB, Mukhutdinova AN, Tyumina HA, Vikhareva HV, Suzina NE, El'-Registan GI, Mulyukin AL. Drotaverine hydrochloride degradation using cyst-like dormant cells of Rhodococcus ruber. Curr Microbiol. 2015 Mar;70(3):307-14. doi: 10.1007/s00284-014-0718-1. Epub 2014 Nov 2. PubMed PMID: 25362511. 4: Tomaszewski D, Bałkota M. Intramuscular Administration of Drotaverine Hydrochloride Decreases Both Incidence of Urinary Retention and Time to Micturition in Orthopedic Patients under Spinal Anesthesia: A Single Blinded Randomized Study. Biomed Res Int. 2015;2015:926953. doi: 10.1155/2015/926953. Epub 2015 Jun 21. PubMed PMID: 26185766; PubMed Central PMCID: PMC4491383. 5: Ibrahim MI, Alzeeniny HA, Ellaithy MI, Salama AH, Abdellatif MA. Drotaverine to improve progression of labor among nulliparous women. Int J Gynaecol Obstet. 2014 Feb;124(2):112-7. doi: 10.1016/j.ijgo.2013.08.013. Epub 2013 Nov 7. PubMed PMID: 24299975. 6: Ivshina IB, Vikhareva EV, Richkova MI, Mukhutdinova AN, Karpenko JN. Biodegradation of drotaverine hydrochloride by free and immobilized cells of Rhodococcus rhodochrous IEGM 608. World J Microbiol Biotechnol. 2012 Oct;28(10):2997-3006. doi: 10.1007/s11274-012-1110-6. Epub 2012 Jun 23. PubMed PMID: 22806740. 7: Dahivelkar PP, Bhoir SI, Bari SB, Surana SJ, Bhagwat AM. Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography. J Chromatogr Sci. 2012 Sep;50(8):694-701. doi: 10.1093/chromsci/bms026. Epub 2012 May 9. PubMed PMID: 22573800. 8: Hassouna ME, Issa YM, Zayed AG. Determination of residues of acetaminophen, caffeine, and drotaverine hydrochloride on swabs collected from pharmaceutical manufacturing equipment using HPLC in support of cleaning validation. J AOAC Int. 2014 Sep-Oct;97(5):1439-45. doi: 10.5740/jaoacint.12-475. PubMed PMID: 25902997. 9: Dash A, Maiti R, Akantappa Bandakkanavar TK, Arora P. Intramuscular drotaverine and diclofenac in acute renal colic: a comparative study of analgesic efficacy and safety. Pain Med. 2012 Mar;13(3):466-71. doi: 10.1111/j.1526-4637.2011.01314.x. Epub 2012 Feb 1. PubMed PMID: 22295884. 10: Demushkin VP, Zhavoronkova EV, Khaspekov LG. Effects of drotaverine hydrochloride on viability of rat cultured cerebellar granulocytes. Bull Exp Biol Med. 2012 Feb;152(4):444-6. English, Russian. PubMed PMID: 22803107. 11: Jain R, Vikas, Rather JA. Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20. Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):333-9. doi: 10.1016/j.colsurfb.2010.09.005. Epub 2010 Sep 15. PubMed PMID: 20889317. 12: Madhu C, Mahavarkar S, Bhave S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Arch Gynecol Obstet. 2010 Jul;282(1):11-5. doi: 10.1007/s00404-009-1188-8. Epub 2009 Jul 31. PubMed PMID: 19644697. 13: Shah SA, Shah DR, Chauhan RS, Jain JR. Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form. Indian J Pharm Sci. 2011 May;73(3):296-300. doi: 10.4103/0250-474X.93520. PubMed PMID: 22457554; PubMed Central PMCID: PMC3309650. 14: Mahaparale S, Telekone RS, Raut RP, Damle SS, Kasture PV. Simultaneous spectrophotometric determination of drotaverine hydrochloride and paracetamol in tablet. Indian J Pharm Sci. 2010 Jan;72(1):133-6. doi: 10.4103/0250-474X.62241. PubMed PMID: 20582207; PubMed Central PMCID: PMC2883218. 15: El-Gindy A, Emara S, Shaaban H. Validation and application of chemometrics-assisted spectrophotometry and liquid chromatography for simultaneous determination of two ternary mixtures containing drotaverine hydrochloride. J AOAC Int. 2010 Mar-Apr;93(2):536-48. PubMed PMID: 20480901. 16: Adel S, ElKasabgy NA. Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation. J Liposome Res. 2014 Jun;24(2):136-49. doi: 10.3109/08982104.2013.857355. Epub 2013 Nov 15. PubMed PMID: 24236529. 17: El-Saharty YS, Metwaly FH, Refaat M, El-Khateeb SZ. Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma. J Pharm Biomed Anal. 2006 Jun 7;41(3):720-4. Epub 2006 Feb 15. PubMed PMID: 16469468. 18: Romics I, Molnár DL, Timberg G, Mrklic B, Jelakovic B, Köszegi G, Blaskó G. The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. BJU Int. 2003 Jul;92(1):92-6. PubMed PMID: 12823389. 19: Singh KC, Jain P, Goel N, Saxena A. Drotaverine hydrochloride for augmentation of labor. Int J Gynaecol Obstet. 2004 Jan;84(1):17-22. PubMed PMID: 14698825. 20: Sharma JB, Pundir P, Kumar A, Murthy NS. Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. Int J Gynaecol Obstet. 2001 Sep;74(3):255-60. PubMed PMID: 11543749.