NCGC00029283 | CAS#714240-31-0 | WRN helicase inhibitor MedKoo

MedKoo Cat#: 565575 | Name: NCGC00029283

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCGC00029283 is a novel inhibitor of the werner syndrome helicase-nuclease (wrn) helicase

Chemical Structure

NCGC00029283

CAS#714240-31-0

Theoretical Analysis

MedKoo Cat#: 565575

Name: NCGC00029283

CAS#: 714240-31-0

Chemical Formula: C18H12FN3O3

Exact Mass: 337.0863

Molecular Weight: 337.31

Elemental Analysis: C, 64.09; H, 3.59; F, 5.63; N, 12.46; O, 14.23

Price and Availability

Size	Price	Availability
500mg	USD 3,650.00	2 months
1g	USD 4,950.00	2 months
2g	USD 7,950.00	2-3 months

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Related CAS #

No Data

Synonym

NCGC00029283; NCGC000 29283; NCGC000-29283

IUPAC/Chemical Name

3-(5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl)-6-methoxyquinolin-2-ol

InChi Key

FJQADEHMIMENRE-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H12FN3O3/c1-24-13-6-7-15-11(8-13)9-14(17(23)20-15)16-21-18(25-22-16)10-2-4-12(19)5-3-10/h2-9H,1H3,(H,20,23)

SMILES Code

OC1=NC2=CC=C(OC)C=C2C=C1C3=NOC(C4=CC=C(F)C=C4)=N3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#A20O12B10

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	6.9	20.57

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 337.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.