Synonym
Drotaverine Free Base; Drotaverina; Drotaverinum; Drotaverin; Isodihydroperparine; dihydroisoperparine;
IUPAC/Chemical Name
1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
InChi Key
OMFNSKIUKYOYRG-MOSHPQCFSA-N
InChi Code
InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13-
SMILES Code
CCOC1=CC2=C(C=C1OCC)CCN/C2=C\C3=CC=C(OCC)C(OCC)=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
397.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. doi: 10.1159/000485921. Epub 2018 Jan 4. PMID: 29301136.
2: Ali S, Corcea SL, Cristian RM, Bumbacea RS. A rapid desensitization protocol in a case of drotaverine-induced serum sickness-like reaction in a pregnant woman: A case report. Exp Ther Med. 2019 Dec;18(6):5105-5107. doi: 10.3892/etm.2019.8170. Epub 2019 Nov 7. PMID: 31819773; PMCID: PMC6895773.
3: Singh KC, Jain P, Goel N, Saxena A. Drotaverine hydrochloride for augmentation of labor. Int J Gynaecol Obstet. 2004 Jan;84(1):17-22. doi: 10.1016/s0020-7292(03)00276-5. PMID: 14698825.
4: Aggarwal V. Drotaverine for Recurrent Abdominal Pain in Children. Indian Pediatr. 2015 Oct;52(10):843-4. PMID: 26499005.
5: Saps M, Miranda A. Gastrointestinal Pharmacology. Handb Exp Pharmacol. 2017;239:147-176. doi: 10.1007/164_2016_119. PMID: 28236087.
6: Patai Z, Guttman A, Mikus EG. Potential L-Type Voltage-Operated Calcium Channel Blocking Effect of Drotaverine on Functional Models. J Pharmacol Exp Ther. 2016 Dec;359(3):442-451. doi: 10.1124/jpet.116.237271. Epub 2016 Oct 13. PMID: 27738091.
7: Dash A, Maiti R, Akantappa Bandakkanavar TK, Arora P. Intramuscular drotaverine and diclofenac in acute renal colic: a comparative study of analgesic efficacy and safety. Pain Med. 2012 Mar;13(3):466-71. doi: 10.1111/j.1526-4637.2011.01314.x. Epub 2012 Feb 1. PMID: 22295884.
8: Pavel IZ, Heller L, Sommerwerk S, Loesche A, Al-Harrasi A, Csuk R. Drotaverine - a Concealed Cytostatic! Arch Pharm (Weinheim). 2017 Jan;350(1). doi: 10.1002/ardp.201600289. Epub 2016 Nov 23. PMID: 27879007.
9: Sharma JB, Pundir P, Kumar A, Murthy NS. Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. Int J Gynaecol Obstet. 2001 Sep;74(3):255-60. doi: 10.1016/s0020-7292(01)00448-9. PMID: 11543749.
10: Ibrahim MI, Alzeeniny HA, Ellaithy MI, Salama AH, Abdellatif MA. Drotaverine to improve progression of labor among nulliparous women. Int J Gynaecol Obstet. 2014 Feb;124(2):112-7. doi: 10.1016/j.ijgo.2013.08.013. Epub 2013 Nov 7. PMID: 24299975.
