Synonym
D-Brompheniramine; Dexbrompheniraminum; Disophrol; Brompheniramine d-; Drixoral
IUPAC/Chemical Name
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine maleate
InChi Key
ZDIGNSYAACHWNL-HNNXBMFYSA-N
InChi Code
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
SMILES Code
CN(C)CC[C@@H](C1=CC=C(Br)C=C1)C2=NC=CC=C2.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
435.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sadofsky LR, Campi B, Trevisani M, Compton SJ, Morice AH. Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Exp Lung Res. 2008 Dec;34(10):681-93. doi: 10.1080/01902140802339623. PubMed PMID: 19085565.
2: Onur F, Yücesoy C, Dermiş S, Kartal M, Kökdil G. Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry. Talanta. 2000 Feb 7;51(2):269-79. PubMed PMID: 18967858.
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6: Smith G, Fred HL. Cutaneous reaction to dexbrompheniramine maleate. Arch Dermatol. 1966 Aug;94(2):200. PubMed PMID: 4380371.
7: OLANSKY S. DEXBROMPHENIRAMINE-FLUPHENAZINE IN THE MANAGEMENT OF PRURITUS: COMPARISON WITH METHDILAZINE. J New Drugs. 1965 Mar-Apr;5(2):117-20. PubMed PMID: 14315150.
8: FIERBERG AA. ALLERGIC NASAL CONGESTION: EFFECTS OF ORAL TREATMENT WITH A COMBINATION OF DEXBROMPHENIRAMINE AND D-ISOEPHEDRINE. Ann Allergy. 1964 Jun;22:324-8. PubMed PMID: 14175193.
9: LINN E, REISS F. ITCHING DERMATOSES TREATED WITH COMBINED DEXBROMPHENIRAMINE-FLUPHENAZINE. A DOUBLE-BLIND COMPARISON WITH TRIMEPRAZINE. Skin (Los Angeles). 1963 Dec;2:374-6. PubMed PMID: 14088566.
10: GOULD AH. Combined dexbrompheniramine-fluphenazine (Diperm chronotab) in the oral treatment of pruritus. J New Drugs. 1962 May-Jun;2:179-82. PubMed PMID: 13900814.