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MedKoo Cat#: 413599 | Name: Dexbrompheniramine free base (S-isomer)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dexbrompheniramine Free Base is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine.

Chemical Structure

Dexbrompheniramine free base (S-isomer)
Dexbrompheniramine free base (S-isomer)
CAS#132-21-8 (free base S-isomer)

Theoretical Analysis

MedKoo Cat#: 413599

Name: Dexbrompheniramine free base (S-isomer)

CAS#: 132-21-8 (free base S-isomer)

Chemical Formula: C16H19BrN2

Exact Mass: 318.0732

Molecular Weight: 319.25

Elemental Analysis: C, 60.20; H, 6.00; Br, 25.03; N, 8.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
980-71-2 (maleate) 86-22-6 (free base) 32656-44-3 (free base R-isomer) 132-21-8 (free base S-isomer) 2391-03-9 (maleate S-isomer)
Synonym
Dexbrompheniramine Free Base; Dexbrompheniraminum; EINECS 205-053-5
IUPAC/Chemical Name
(S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
InChi Key
ZDIGNSYAACHWNL-HNNXBMFYSA-N
InChi Code
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
SMILES Code
CN(C)CC[C@@H](C1=CC=C(Br)C=C1)C2=NC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Dexbrompheniramine. 2018 Oct 31. PMID: 30000837. 2: Lin CC, Kim HK, Lim J, Digiore C, Symchowicz S, Gural R. Steady-state bioavailability of dexbrompheniramine and pseudoephedrine from a repeat-action combination tablet. J Pharm Sci. 1985 Jan;74(1):25-8. doi: 10.1002/jps.2600740107. PMID: 3981411. 3: Sadofsky LR, Campi B, Trevisani M, Compton SJ, Morice AH. Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Exp Lung Res. 2008 Dec;34(10):681-93. doi: 10.1080/01902140802339623. PMID: 19085565. 4: Kapstad B, Warland A. Therapeutic effectiveness of an oral anti-histamine combination (dexbrompheniramine maleate/d-isoephedrine sulphate) in the treatment of patients with allergic rhinitis. Acta Allergol. 1976 Jun;31(3):223-6. doi: 10.1111/j.1398-9995.1976.tb01682.x. PMID: 782134. 5: Marák J, Mikus P, Maráková K, Kaniansky D, Valásková I, Havránek E. Potentialities of ITP-CZE method with diode array detection for enantiomeric purity control of dexbrompheniramine in pharmaceuticals. J Pharm Biomed Anal. 2008 Apr 14;46(5):870-6. doi: 10.1016/j.jpba.2007.05.019. Epub 2007 May 25. PMID: 17618074. 6: Arroll B. Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir Med. 2005 Dec;99(12):1477-84. doi: 10.1016/j.rmed.2005.09.039. PMID: 16291073. 7: Berdy GJ, Abelson MB, George MA, Smith LM, Giovanoni RL. Allergic conjunctivitis: a survey of new antihistamines. J Ocul Pharmacol. 1991 Winter;7(4):313-24. doi: 10.1089/jop.1991.7.313. PMID: 1687324. 8: Smith G, Fred HL. Cutaneous reaction to dexbrompheniramine maleate. Arch Dermatol. 1966 Aug;94(2):200. PMID: 4380371. 9: FIERBERG AA. ALLERGIC NASAL CONGESTION: EFFECTS OF ORAL TREATMENT WITH A COMBINATION OF DEXBROMPHENIRAMINE AND D-ISOEPHEDRINE. Ann Allergy. 1964 Jun;22:324-8. PMID: 14175193. 10: Onur F, Yücesoy C, Dermiş S, Kartal M, Kökdil G. Simultaneous determination of pseudoephedrine sulfate, dexbrompheniramine maleate and loratadine in pharmaceutical preparations using derivative spectrophotometry and ratio spectra derivative spectrophotometry. Talanta. 2000 Feb 7;51(2):269-79. doi: 10.1016/s0039-9140(99)00256-8. PMID: 18967858.