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MedKoo Cat#: 584603 | Name: Brompheniramine free base (R-isomer)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Brompheniramine, (R)- is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.

Chemical Structure

Brompheniramine free base (R-isomer)
Brompheniramine free base (R-isomer)
CAS#32656-44-3 (free base R-isomer)

Theoretical Analysis

MedKoo Cat#: 584603

Name: Brompheniramine free base (R-isomer)

CAS#: 32656-44-3 (free base R-isomer)

Chemical Formula: C16H19BrN2

Exact Mass: 318.0732

Molecular Weight: 319.25

Elemental Analysis: C, 60.20; H, 6.00; Br, 25.03; N, 8.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
980-71-2 (maleate) 86-22-6 (free base) 32656-44-3 (free base R-isomer) 132-21-8 (free base S-isomer) 2391-03-9 (maleate S-isomer)
Synonym
Brompheniramine, (R)-; Dimetapp; (-)-Brompheniramine; (R)-Brompheniramine; L-Brompheniramine; Brompheniramine free base (R-isomer)
IUPAC/Chemical Name
(R)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
InChi Key
ZDIGNSYAACHWNL-OAHLLOKOSA-N
InChi Code
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m1/s1
SMILES Code
CN(C)CC[C@H](C1=CC=C(Br)C=C1)C2=NC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Simons FE, Frith EM, Simons KJ (December 1982). "The pharmacokinetics and antihistaminic effects of brompheniramine". The Journal of Allergy and Clinical Immunology. 70 (6): 458–64. doi:10.1016/0091-6749(82)90009-4. PMID 6128358. 2. Barondes, Samuel H. (2003). Better Than Prozac. New York: Oxford University Press. pp. 39–40. ISBN 0-19-515130-5. 3. Salahudeen MJ; Duffull SB; Nishtala PS; et al. (2015-03-25). "Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review". BMC Geriatrics. 15 (31). doi:10.1186/s12877-015-0029-9. PMC 4377853. PMID 25879993. 4. L.A. Walter, U.S. Patent 3,061,517 (1962) 5. L.A. Walter, U.S. Patent 3,030,371 (1962)