Synonym
Decamethonium; Decamethonum; Syncurine; Decamethonium ion; Lopac-D-1260; (DM)Br2; Decamethonium dibromide; Decamethonium bromide Decacuran; C 10
IUPAC/Chemical Name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium bromide
InChi Key
HLXQFVXURMXRPU-UHFFFAOYSA-L
InChi Code
InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
418.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Brown TC. Aspects of depolarizing neuromuscular blockers: decamethonium and suxamethonium. Paediatr Anaesth. 2013 Sep;23(9):868-70. doi: 10.1111/pan.12122. Epub 2013 Feb 11. PubMed PMID: 23398375.
2: Poulsen H, Hougs W. The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39. Acta Anaesthesiol Scand. 2007 Sep;51(8):1018-42; discussion 1043. PubMed PMID: 17697296.
3: Ball C, Westhorpe R. Muscle relaxants--decamethonium. Anaesth Intensive Care. 2005 Dec;33(6):709. PubMed PMID: 16398373.
4: Macharia R, Patel K, Otto WR, McKinnell IW, Christ B. Decamethonium bromide-mediated inhibition of embryonic muscle development. Anat Embryol (Berl). 2004 Apr;208(1):75-85. Epub 2004 Mar 3. PubMed PMID: 14997390.
5: Lee C, Jones T. Molecular conformation-activity relationship of decamethonium congeners. Br J Anaesth. 2002 May;88(5):692-9. PubMed PMID: 12067008.
6: Redai I, Richards KM, England AJ, Feldman SA. Interaction of decamethonium with hexamethonium or vecuronium in the rat: an isobolographic analysis. Anesth Analg. 1995 Oct;81(4):768-72. PubMed PMID: 7574008.
7: Gu Y, Lee H, Hudson RA. Bis-catechol-substituted redox-reactive analogues of hexamethonium and decamethonium: stimulated affinity-dependent reactivity through iron peroxide catalysis. J Med Chem. 1994 Dec 9;37(25):4417-20. PubMed PMID: 7996555.
8: Effraim KD, Ahmad K. Short communication on erythrocyte membrane stabilization by decamethonium and succinylcholine. Cent Afr J Med. 1994 May;40(5):134-6. PubMed PMID: 7954726.
9: Campkin NT, Hood JR, Feldman SA. Resistance to decamethonium neuromuscular block after prior administration of vecuronium. Anesth Analg. 1993 Jul;77(1):78-80. PubMed PMID: 8100407.
10: Feldman S, Fauvel N. Potentiation and antagonism of vecuronium by decamethonium. Anesth Analg. 1993 Mar;76(3):631-4. PubMed PMID: 8095780.
