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MedKoo Cat#: 581736 | Name: Decamethonium chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Decamethonium is a depolarizing muscle relaxant or neuromuscular blocking agent,[1] and is used in anesthesia to induce paralysis.

Chemical Structure

Decamethonium chloride
Decamethonium chloride
CAS#3198-38-7 (chloride)

Theoretical Analysis

MedKoo Cat#: 581736

Name: Decamethonium chloride

CAS#: 3198-38-7 (chloride)

Chemical Formula: C16H38Cl2N2

Exact Mass: 328.2412

Molecular Weight: 329.39

Elemental Analysis: C, 58.34; H, 11.63; Cl, 21.52; N, 8.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1420-40-2 (iodide) 156-74-1 (cation) 3198-38-7 (chloride) 541-22-0 (bromide)
Synonym
Decamethonium chloride; Decamethonium dichloride; Decamethylenebis(trimethylammonium chloride).
IUPAC/Chemical Name
1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (9CI)
InChi Key
KMVDECFGXJKYHV-UHFFFAOYSA-L
InChi Code
InChI=1S/C16H38N2.2ClH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Cl-].[Cl-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 329.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arseniuk VV, Bartosh AM, Vasul'ianov DS, Voĭtenko II, Hryniv OV, Smotrov MI. [Probability of incidence of abdominal adhesional process in peritonitis, depending on the sanation preparation applied]. Klin Khir. 2014 Dec;(12):78. Ukrainian. PubMed PMID: 25842895. 2: Kiss T, Krajcs N, Pirger Z, Hernádi L. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One. 2014 Oct 10;9(10):e109538. doi: 10.1371/journal.pone.0109538. eCollection 2014. PubMed PMID: 25303328; PubMed Central PMCID: PMC4193815. 3: Poulsen H, Hougs W. The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39. Acta Anaesthesiol Scand. 2007 Sep;51(8):1018-42; discussion 1043. PubMed PMID: 17697296. 4: Basu S, Chaudhuri T, Chauhan SP, Das Gupta AK, Chaudhury L, Vedasiromoni JR. The theaflavin fraction is responsible for the facilitatory effect of black tea at the skeletal myoneural junction. Life Sci. 2005 May 13;76(26):3081-8. Epub 2005 Jan 28. PubMed PMID: 15850600. 5: Sachs JR, Martin DW. Role of polyamine structure in inhibition of K+-Cl- cotransport in human red cell ghosts. J Physiol. 1999 Nov 1;520 Pt 3:723-35. PubMed PMID: 10545139; PubMed Central PMCID: PMC2269624. 6: Luo C, Ashani Y, Doctor BP. Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands. Mol Pharmacol. 1998 Apr;53(4):718-26. PubMed PMID: 9547363. 7: Roche ME, Anderson MA, Oda RP, Riggs BL, Strausbauch MA, Okazaki R, Wettstein PJ, Landers JP. Capillary electrophoresis of insulin-like growth factors: enhanced ultraviolet detection using dynamically coated capillaries and on-line solid-phase extraction. Anal Biochem. 1998 Apr 10;258(1):87-95. PubMed PMID: 9527853. 8: Das M, Vedasiromoni JR, Chauhan SP, Ganguly DK. Effect of green tea (Camellia sinensis) extract on the rat diaphragm. J Ethnopharmacol. 1997 Aug;57(3):197-201. PubMed PMID: 9292413. 9: Brotz TM, Borst A. Cholinergic and GABAergic receptors on fly tangential cells and their role in visual motion detection. J Neurophysiol. 1996 Sep;76(3):1786-99. PubMed PMID: 8890292. 10: Liao J, Heider H, Sun MC, Stieger S, Brodbeck U. The monoclonal antibody 2G8 is carbohydrate-specific and distinguishes between different forms of vertebrate cholinesterases. Eur J Biochem. 1991 May 23;198(1):59-65. PubMed PMID: 2040291. 11: Payne CS, Saeed M, Wolfe AD. Ligand stabilization of cholinesterases. Biochim Biophys Acta. 1989 Nov 9;999(1):46-51. PubMed PMID: 2804138. 12: Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P. Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action. Mol Pharmacol. 1989 Sep;36(3):349-54. PubMed PMID: 2779521. 13: Demarest JR, Finn AL. Characterization of the basolateral membrane conductance of Necturus urinary bladder. J Gen Physiol. 1987 Apr;89(4):541-62. PubMed PMID: 2438371; PubMed Central PMCID: PMC2215918. 14: Young JA, Cook DI, Evans LA, Pirani D. Effects of ion transport inhibition on rat mandibular gland secretion. J Dent Res. 1987 Feb;66(2):531-6. PubMed PMID: 2442220. 15: Mil'kov BO, Shampeĭ GP, Kulachek FG, Deĭbuk GD, Klimenko AN. [Methods of sanation of the abdominal cavity in acute peritonitis]. Klin Khir. 1986;(4):21-3. Russian. PubMed PMID: 3713008. 16: Mindel JS, Eisenkraft JB, Raab EL, Teutsch G. Succinyldicholine and the basic ocular deviation. Am J Ophthalmol. 1983 Mar;95(3):315-26. PubMed PMID: 6829678. 17: McLaughlin A, Eng WK, Vaio G, Wilson T, McLaughlin S. Dimethonium, a divalent cation that exerts only a screening effect on the electrostatic potential adjacent to negatively charged phospholipid bilayer membranes. J Membr Biol. 1983;76(2):183-93. PubMed PMID: 6242893. 18: Read GW, Hong SM, Kiefer EF. Competitive inhibition of 48/80-induced histamine release by benzalkonium chloride and its analogs and the polyamine receptor in mast cells. J Pharmacol Exp Ther. 1982 Sep;222(3):652-7. PubMed PMID: 6180160. 19: Kharkevich DA, Fisenko VP. The effect of neuromuscular blocking agents on the acetylcholine receptors of different skeletal muscles. Arch Int Pharmacodyn Ther. 1981 Jun;251(2):255-69. PubMed PMID: 6269508. 20: Ono JK, Salvaterra PM. Snake alpha-toxin effects on cholinergic and noncholinergic responses of Aplysia californica neurons. J Neurosci. 1981 Mar;1(3):259-70. PubMed PMID: 6114995.