MedKoo Cat#: 317508 | Name: Chloroprocaine Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chloroprocaine Hydrochloride is a synthetic, local anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.

Chemical Structure

Chloroprocaine Hydrochloride
Chloroprocaine Hydrochloride
CAS#3858-89-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 317508

Name: Chloroprocaine Hydrochloride

CAS#: 3858-89-7 (HCl)

Chemical Formula: C13H20Cl2N2O2

Exact Mass: 0.0000

Molecular Weight: 307.22

Elemental Analysis: C, 50.82; H, 6.56; Cl, 23.08; N, 9.12; O, 10.42

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Synonym
Chloroprocaine Hydrochloride; CHEBI:3637; UNII-LT7Z1YW11H; NCGC00183273-01; Nesacaine (TN); Nesacaine MPF;
IUPAC/Chemical Name
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate;hydrochloride
InChi Key
SZKQYDBPUCZLRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14;/h5-6,9H,3-4,7-8,15H2,1-2H3;1H
SMILES Code
CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 307.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Columb MO, Lyons G, Naughton NN, Becton WW. Determination of the minimum local analgesic concentration of epidural chloroprocaine hydrochloride in labor. Int J Obstet Anesth. 1997 Jan;6(1):39-42. PubMed PMID: 15321309. 2: TRAVIN MS. USE OF 2-CHLOROPROCAINE HYDROCHLORIDE AS AN ANESTHETIC AGENT FOR ORAL SURGERY: CLINCIAL IMPRESSIONS. J Oral Ther Pharmacol. 1965 May;1:637-40. PubMed PMID: 14292260. 3: WALL B. The use of chloroprocaine hydrochloride (nesacaine) for topical anesthesia in the genitourinary tract. J Urol. 1959 Jul;82(1):168-70. PubMed PMID: 13665829. 4: ORBACH EJ. Chloroprocaine hydrochloride: clinical evaluation in office surgery. Am Pract Dig Treat. 1959 Feb;10(2):231-4. PubMed PMID: 13627399. 5: Menon G, Norris B, Webster J. Simultaneous determination of chloroprocaine hydrochloride and its degradation product 4-amino-2-chlorobenzoic acid in bulk drug and injection solutions by high-performance liquid chromatography. J Pharm Sci. 1984 Feb;73(2):251-3. PubMed PMID: 6707895. 6: Scott DB. Chloroprocaine hydrochloride and obstetric analgesia. Anaesthesia. 1980 May;35(5):518. PubMed PMID: 7396160. 7: Allen PR, Johnson RW. Extradural analgesia in labour. A comparison of 2-chloroprocaine hydrochloride and bupivacaine hydrochloride. Anaesthesia. 1979 Oct;34(9):839-43. PubMed PMID: 532919. 8: KRUMPERMAN LW, MESCHTER SC, CLOSE EL, WESTER MR, ERICKSON JC, STRENGE HJ. Transdural diffusion of 2-chloroprocaine hydrochloride in man. Anesth Analg. 1960 Jan-Feb;39:55-8. PubMed PMID: 14412260. 9: CHLOROPROCAINE hydrochloride. J Am Med Assoc. 1957 Jan 5;163(1):38-9. PubMed PMID: 13376341. 10: COLAVINCENZO JW, FOLDES FF, MCNALL PG, FRIDAY RH. The use of 2-chloroprocaine hydrochloride for epidural block in outpatients. Pa Med J. 1956 Mar;59(3):338-40. PubMed PMID: 13297535.