Synonym
Chloroprocaine; HSDB3301; HSDB-3301; HSDB 3301
IUPAC/Chemical Name
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
InChi Key
VDANGULDQQJODZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
SMILES Code
CCN(CCOC(C1=C(Cl)C=C(N)C=C1)=O)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
270.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tonder S, Togioka BM, Maani CV. Chloroprocaine. 2020 Aug 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 30422496.
2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Chloroprocaine. 2018 Oct 31. PMID: 30000670.
3: Veneziano G, Tobias JD. Chloroprocaine for epidural anesthesia in infants and children. Paediatr Anaesth. 2017 Jun;27(6):581-590. doi: 10.1111/pan.13134. Epub 2017 Mar 21. PMID: 28321983.
4: Sweet E, Shusterman CS, Nedeljkovic MS, Solodiuk JC. Nurse Practitioner- Administered Chloroprocaine in Children with Postoperative Pain. Pain Manag Nurs. 2018 Aug;19(4):424-429. doi: 10.1016/j.pmn.2017.11.003. Epub 2018 Mar 2. PMID: 29503214.
5: Johnson RW. Chloroprocaine. Anaesthesia. 1979 Oct;34(9):837-8. doi: 10.1111/j.1365-2044.1979.tb08531.x. PMID: 532918.
6: Kim DH, Kahn R, Lee A, Mac PD, Chiu YF, Yadeau J, Liu J. Chloroprocaine Provides Safe, Effective, Short-Acting Spinal Anesthesia Ideal for Ambulatory Surgeries: A Retrospective Review. HSS J. 2020 Dec;16(Suppl 2):280-284. doi: 10.1007/s11420-019-09713-y. Epub 2019 Aug 26. PMID: 33380957; PMCID: PMC7749923.
7: Shah J, Votta-Velis EG, Borgeat A. New local anesthetics. Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):179-185. doi: 10.1016/j.bpa.2018.06.010. Epub 2018 Jul 3. PMID: 30322458.
8: Wesselink E, Hurk GJD, Vegt RV, Slagt C, Aa JV, Franssen E, Ven PV, Swart N, Boer C, Leeuw M. Chloroprocaine versus prilocaine for spinal anesthesia in ambulatory knee arthroscopy: a double-blind randomized trial. Reg Anesth Pain Med. 2019 Aug 21:rapm-2019-100673. doi: 10.1136/rapm-2019-100673. Epub ahead of print. PMID: 31439640.
9: Marx GF, Finster M. Chloroprocaine. Anaesthesia. 1982 Mar;37(3):349-50. doi: 10.1111/j.1365-2044.1982.tb01125.x. PMID: 7091616.
10: Herndon CL, Martinez R, Sarpong NO, Geller JA, Shah RP, Cooper HJ. Spinal Anesthesia Using Chloroprocaine is Safe, Effective, and Facilitates Earlier Discharge in Selected Fast-track Total Hip Arthroplasty. Arthroplast Today. 2020 Jun 1;6(3):305-308. doi: 10.1016/j.artd.2020.04.007. PMID: 32509943; PMCID: PMC7264955.