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MedKoo Cat#: 540071 | Name: Chlorophyllin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorophyllin is a semi-synthetic derivative of chlorophyll commercially used as a food additive and color agent. It is known to induce apoptosis and autophagy under UV light in bladder cancer cells and suppresses benz[a]pyrene- and DBP induced carcinogenesis.

Chemical Structure

Chlorophyllin
Chlorophyllin
CAS#15611-43-5

Theoretical Analysis

MedKoo Cat#: 540071

Name: Chlorophyllin

CAS#: 15611-43-5

Chemical Formula: C34H31MgN4O63

Exact Mass: 615.2110

Molecular Weight: 615.95

Elemental Analysis: C, 66.30; H, 5.07; Mg, 3.95; N, 9.10; O, 15.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CCRIS 8573; CCRIS8573; CCRIS-8573; Chlorophyllin; Chlorophyllin A
IUPAC/Chemical Name
monomagnesium mono((7S,8R)-3-carboxylato-7-(2-carboxylatoethyl)-5-(carboxylatomethyl)-18-ethyl-2,8,12,17-tetramethyl-13-vinyl-7H,8H-porphyrin-21,23-diide)
InChi Key
UVOXKYYHMDAWNK-JKSHRDEXSA-I
InChi Code
InChI=1S/C34H36N4O6.Mg/c1-7-19-15(3)23-12-25-17(5)21(9-10-29(39)40)32(37-25)22(11-30(41)42)33-31(34(43)44)18(6)26(38-33)14-28-20(8-2)16(4)24(36-28)13-27(19)35-23;/h7,12-14,17,21H,1,8-11H2,2-6H3,(H5,35,36,37,38,39,40,41,42,43,44);/q;+2/p-5/t17-,21+;/m1./s1
SMILES Code
[O-]C(c1c(c(CC([O-])=O)c2nc([C@H](C)[C@@H]2CCC([O-])=O)cc([n-]3)c(C)c(C=C)c3cc4nc(C(CC)=C4C)c5)[n-]c5c1C)=O.[Mg+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 615.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Häder DP, Schmidl J, Hilbig R, Oberle M, Wedekind H, Richter PR. Treatment of ichthyophthiriasis with photodynamically active chlorophyllin. Parasitol Res. 2016 Apr;115(4):1509-17. doi: 10.1007/s00436-015-4884-2. Epub 2015 Dec 23. PubMed PMID: 26693716. 2: Singh DJ, Singh DK. ANTHELMINTIC ACTIVITY OF CHLOROPHYLLIN AGAINST DIFFERENT LARVAL STAGES OF Fasciola gigantica. Rev Inst Med Trop Sao Paulo. 2016;58:39. doi: 10.1590/S1678-9946201658039. Epub 2016 May 24. PubMed PMID: 27253741; PubMed Central PMCID: PMC4879996. 3: Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur SK, Sainis KB. Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis. Free Radic Biol Med. 2015 Aug;85:56-70. doi: 10.1016/j.freeradbiomed.2015.04.007. Epub 2015 Apr 11. PubMed PMID: 25872101. 4: Chaturvedi D, Singh VK. Toxicity of Chlorophyllin against Lymnaea acuminata at Different Wavelengths of Visible Light. Trop Life Sci Res. 2016 Aug;27(2):25-36. doi: 10.21315/tlsr2016.27.2.3. PubMed PMID: 27688849; PubMed Central PMCID: PMC5031161. 5: Lihuan D, Jingcun Z, Ning J, Guozeng W, Yiwei C, Wei L, Jing Q, Yuanfang Z, Gang C. Photodynamic therapy with the novel photosensitizer chlorophyllin f induces apoptosis and autophagy in human bladder cancer cells. Lasers Surg Med. 2014 Apr;46(4):319-34. doi: 10.1002/lsm.22225. Epub 2014 Jan 24. PubMed PMID: 24464873. 6: Strompfová V, Kubašová I, Farbáková J, Gancarčíková S, Mudroňová D, Maďari A, Lauková A. Experimental application of Lactobacillus fermentum CCM 7421 in combination with chlorophyllin in dogs. Appl Microbiol Biotechnol. 2015 Oct;99(20):8681-90. doi: 10.1007/s00253-015-6724-9. Epub 2015 Jun 11. PubMed PMID: 26062536. 7: Thiyagarajan P, Kavitha K, Thautam A, Dixit M, Nagini S. Dietary chlorophyllin abrogates TGFβ signaling to modulate the hallmark capabilities of cancer in an animal model of forestomach carcinogenesis. Tumour Biol. 2014 Jul;35(7):6725-37. doi: 10.1007/s13277-014-1849-5. Epub 2014 Apr 9. PubMed PMID: 24715303. 8: Singh DJ, Singh DK. Toxicity of chlorophyllin in different wavelengths of visible light against Fasciola gigantica larvae. J Photochem Photobiol B. 2015 Mar;144:57-60. doi: 10.1016/j.jphotobiol.2015.01.016. Epub 2015 Feb 16. PubMed PMID: 25720554. 9: McCook JP, Dorogi PL, Vasily DB, Cefalo DR. In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs. Clin Cosmet Investig Dermatol. 2015 Aug 12;8:443-8. doi: 10.2147/CCID.S86863. eCollection 2015. PubMed PMID: 26300653; PubMed Central PMCID: PMC4536759. 10: Du L, Jiang N, Wang G, Chu Y, Lin W, Qian J, Zhang Y, Zheng J, Chen G. Autophagy inhibition sensitizes bladder cancer cells to the photodynamic effects of the novel photosensitizer chlorophyllin e4. J Photochem Photobiol B. 2014 Apr 5;133:1-10. doi: 10.1016/j.jphotobiol.2014.02.010. Epub 2014 Feb 27. PubMed PMID: 24650577. 11: Häder DP, Schmidl J, Hilbig R, Oberle M, Wedekind H, Richter P. Fighting fish parasites with photodynamically active chlorophyllin. Parasitol Res. 2016 Jun;115(6):2277-83. doi: 10.1007/s00436-016-4972-y. Epub 2016 Mar 3. PubMed PMID: 26936032. 12: Buchovec I, Lukseviciute V, Marsalka A, Reklaitis I, Luksiene Z. Effective photosensitization-based inactivation of Gram (-) food pathogens and molds using the chlorophyllin-chitosan complex: towards photoactive edible coatings to preserve strawberries. Photochem Photobiol Sci. 2016 Apr;15(4):506-16. doi: 10.1039/c5pp00376h. Epub 2016 Mar 7. PubMed PMID: 26947225. 13: Nagini S, Vidya Priyadarsini R, Veeravarmal V, Mishra R. Chlorophyllin abrogates canonical Wnt/β-catenin signaling and angiogenesis to inhibit the development of DMBA-induced hamster cheek pouch carcinomas. Cell Oncol (Dordr). 2012 Oct;35(5):385-95. Epub 2012 Sep 15. Erratum in: Cell Oncol (Dordr). 2013 Apr;36(2):179. Siddavaram, Nagini [corrected to Nagini, Siddavaram]; Ramamurthi, Vidya Priyadarsini [corrected to Vidya Priyadarsini, Ramamurthi]; Veeran, Veeravarmal [corrected to Veeravarmal, Veeran]. PubMed PMID: 22983718. 14: Abdel-Latif MS, Elmeleigy KM, Aly TA, Khattab MS, Mohamed SM. Pathological and biochemical evaluation of coumarin and chlorophyllin against aflatoxicosis in rat. Exp Toxicol Pathol. 2017 Feb 9. pii: S0940-2993(16)30357-8. doi: 10.1016/j.etp.2017.01.014. [Epub ahead of print] PubMed PMID: 28190563. 15: McCook JP, Stephens TJ, Jiang LI, Law RM, Gotz V. Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix. Clin Cosmet Investig Dermatol. 2016 Jul 25;9:167-74. doi: 10.2147/CCID.S111139. eCollection 2016. PubMed PMID: 27524916; PubMed Central PMCID: PMC4966572. 16: Li B, Wu Z, Li W, Jia G, Lu J, Fang J, Chen G. Chlorophyllin e4 is a novel photosensitizer against human bladder cancer cells. Oncol Rep. 2012 May;27(5):1455-60. doi: 10.3892/or.2012.1656. Epub 2012 Jan 26. PubMed PMID: 22294235. 17: Zhang J, Wang W, Yang F, Zhou X, Jin H, Yang PY. Comparative proteomic analysis of drug sodium iron chlorophyllin addition to Hep 3B cell line. Analyst. 2012 Sep 21;137(18):4287-94. doi: 10.1039/c2an35436e. Epub 2012 Aug 1. PubMed PMID: 22852132. 18: Sigler ML, Stephens TJ. Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin. J Drugs Dermatol. 2015 Apr;14(4):401-4. PubMed PMID: 25844615. 19: Stephens TJ, McCook JP, Herndon JH Jr. Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores. J Drugs Dermatol. 2015 Jun;14(6):589-92. PubMed PMID: 26091384. 20: Thiyagarajan P, Senthil Murugan R, Kavitha K, Anitha P, Prathiba D, Nagini S. Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis. Food Chem Toxicol. 2012 Mar;50(3-4):867-76. doi: 10.1016/j.fct.2011.12.019. Epub 2011 Dec 21. PubMed PMID: 22210229.