Chloramphenicol | CAS#56-75-7 | CAS#530-43-8 | Bacteriostatic Antibiotic

MedKoo Cat#: 558235 | Name: Chloramphenicol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chloramphenicol is a bacteriostatic antibiotic that inhibits bacterial protein synthesis. It is usually bacteristatic and effective against a wide range of gram-positive and gram-negative organisms. Chloramphenicol is used as a selection agent for transformed cells containing chloramphenicol resistance genes. Chloramphenicol exhibits anti-rickettsial activity and is also active against chlamydias of the psittacosis-lymphogranuloma group.

Chemical Structure

Chloramphenicol

CAS#56-75-7 (free)

Theoretical Analysis

MedKoo Cat#: 558235

Name: Chloramphenicol

CAS#: 56-75-7 (free)

Chemical Formula: C11H12Cl2N2O5

Exact Mass: 322.0123

Molecular Weight: 323.13

Elemental Analysis: C, 40.89; H, 3.74; Cl, 21.94; N, 8.67; O, 24.76

Price and Availability

Size	Price	Availability
1g	USD 150.00	2 weeks
5g	USD 250.00	2 weeks
10g	USD 400.00	2 weeks
25g	USD 650.00	2 weeks

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Related CAS #

31342-36-6 (pantothenate complex) 982-57-0 (sodium succinate) 3544-94-3 (succinate) 16255-48-4 (stearate) 530-43-8 (palmitate) 716-61-0 (base) 56-75-7 (free)

Synonym

Chloramphenicol; Chlornitromycin; Chloromycetin; Levomycetin; Chlorocid; Globenicol; Detreomycin; Kloramfenikol; Levomycetin; Ophthochlor; Syntomycin;

IUPAC/Chemical Name

2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide

InChi Key

WIIZWVCIJKGZOK-RKDXNWHRSA-N

InChi Code

InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

SMILES Code

C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

Appearance

White to off-white crystalline powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 323.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Engineered "hot" core-shell nanostructures for patterned detection of chloramphenicol. Biosens Bioelectron. 2015 Nov 4;78:67-72. doi: 10.1016/j.bios.2015.11.011. [Epub ahead of print] PubMed PMID: 26594888. 5: Wenhai C, Tengfei C, Erdeng D, Deng Y, Yingqing G, Naiyun G. Increased formation of halomethanes during chlorination of chloramphenicol in drinking water by UV irradiation, persulfate oxidation, and combined UV/persulfate pre-treatments. Ecotoxicol Environ Saf. 2015 Oct 26;124:147-154. doi: 10.1016/j.ecoenv.2015.10.016. [Epub ahead of print] PubMed PMID: 26513530. 6: Franchino A, Jakubec P, Dixon DJ. Enantioselective synthesis of (-)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction. Org Biomol Chem. 2015 Oct 29. [Epub ahead of print] PubMed PMID: 26510469. 7: He J, Cui J. Malachite green and chloramphenicol in aquatic products from regions around Dongting Lake in Hunan, China. Food Addit Contam Part B Surveill. 2015 Nov 24:1-6. [Epub ahead of print] PubMed PMID: 26496159. 8: Yang T, Chen H, Ge T, Wang J, Li W, Jiao K. Highly sensitive determination of chloramphenicol based on thin-layered MoS2/polyaniline nanocomposite. Talanta. 2015 Nov 1;144:1324-8. doi: 10.1016/j.talanta.2015.08.004. Epub 2015 Aug 3. PubMed PMID: 26452965. 9: Ebarvia BS, Ubando IE, Sevilla FB 3rd. Biomimetic piezoelectric quartz crystal sensor with chloramphenicol-imprinted polymer sensing layer. Talanta. 2015 Nov 1;144:1260-5. doi: 10.1016/j.talanta.2015.08.001. Epub 2015 Aug 6. PubMed PMID: 26452956. 10: Choi I, Kim DE, Ahn JH, Yeo WS. On-chip enzymatic assay for chloramphenicol acetyltransferase using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Colloids Surf B Biointerfaces. 2015 Sep 30;136:465-469. doi: 10.1016/j.colsurfb.2015.09.052. [Epub ahead of print] PubMed PMID: 26448379. 11: Chanta C, Phloenchaiwanit P. Randomized Controlled Trial of Azithromycin versus Doxycycline or Chloramphenicol for Treatment of Uncomplicated Pediatric Scrub Typhus. J Med Assoc Thai. 2015 Aug;98(8):756-60. PubMed PMID: 26437532. 12: Xiao Z, Song R, Rao Z, Wei S, Jia Z, Suo D, Fan X. Development of a subcritical water extraction approach for trace analysis of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in poultry tissues. J Chromatogr A. 2015 Oct 30;1418:29-35. doi: 10.1016/j.chroma.2015.09.047. Epub 2015 Sep 24. PubMed PMID: 26433266. 13: Black LA, Higgins DP, Govendir M. In vitro activity of chloramphenicol, florfenicol and enrofloxacin against Chlamydia pecorum isolated from koalas (Phascolarctos cinereus). Aust Vet J. 2015 Nov;93(11):420-3. doi: 10.1111/avj.12364. Epub 2015 Sep 27. PubMed PMID: 26412342. 14: González-Prieto C, Agúndez L, Llosa M. Chloramphenicol Selection of IS10 Transposition in the cat Promoter Region of Widely Used Cloning Vectors. PLoS One. 2015 Sep 16;10(9):e0138615. doi: 10.1371/journal.pone.0138615. eCollection 2015. PubMed PMID: 26375469; PubMed Central PMCID: PMC4574204. 15: Wang Y, Li X, Zhang Z, Ding S, Jiang H, Li J, Shen J, Xia X. Simultaneous determination of nitroimidazoles, benzimidazoles, and chloramphenicol components in bovine milk by ultra-high performance liquid chromatography-tandem mass spectrometry. Food Chem. 2016 Feb 1;192:280-7. doi: 10.1016/j.foodchem.2015.07.033. Epub 2015 Jul 8. PubMed PMID: 26304348. 16: Lu Y, Yao H, Li C, Han J, Tan Z, Yan Y. Separation, concentration and determination of trace chloramphenicol in shrimp from different waters by using polyoxyethylene lauryl ether-salt aqueous two-phase system coupled with high-performance liquid chromatography. Food Chem. 2016 Feb 1;192:163-70. doi: 10.1016/j.foodchem.2015.06.086. Epub 2015 Jul 3. PubMed PMID: 26304334. 17: Hao L, Duan N, Wu S, Xu B, Wang Z. Chemiluminescent aptasensor for chloramphenicol based on N-(4-aminobutyl)-N-ethylisoluminol-functionalized flower-like gold nanostructures and magnetic nanoparticles. Anal Bioanal Chem. 2015 Oct;407(26):7907-15. doi: 10.1007/s00216-015-8957-y. Epub 2015 Aug 22. PubMed PMID: 26297462. 18: Kostopoulou ON, Magoulas GE, Papadopoulos GE, Mouzaki A, Dinos GP, Papaioannou D, Kalpaxis DL. Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells. PLoS One. 2015 Aug 12;10(8):e0134526. doi: 10.1371/journal.pone.0134526. eCollection 2015. PubMed PMID: 26267355; PubMed Central PMCID: PMC4533973. 19: Liu Y, Yan K, Okoth OK, Zhang J. A label-free photoelectrochemical aptasensor based on nitrogen-doped graphene quantum dots for chloramphenicol determination. Biosens Bioelectron. 2015 Dec 15;74:1016-21. doi: 10.1016/j.bios.2015.07.067. Epub 2015 Jul 30. 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