DYR219 | DYRK1 inhibitor

MedKoo Cat#: 128022 | Name: DYR219

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DYR219 is a DYRK1 inhibitor.

Chemical Structure

DYR219

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128022

Name: DYR219

CAS#: N/A

Chemical Formula: C20H15N3O2

Exact Mass: 329.1164

Molecular Weight: 329.36

Elemental Analysis: C, 72.94; H, 4.59; N, 12.76; O, 9.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DYR219; DYR-219; DYR 219

IUPAC/Chemical Name

methyl 4-(6-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)benzoate

InChi Key

FECWKKFFXFRMBE-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H15N3O2/c1-25-20(24)15-2-5-17(6-3-15)23-13-22-18-7-4-16(12-19(18)23)14-8-10-21-11-9-14/h2-13H,1H3

SMILES Code

O=C(OC)C(C=C1)=CC=C1N2C3=CC(C4=CC=NC=C4)=CC=C3N=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 329.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu B, Parsons T, Foley C, Shaw Y, Dunckley T, Hulme C, Hodge JJL. DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity. Sci Rep. 2022 Sep 23;12(1):15847. doi: 10.1038/s41598-022-19967-y. PMID: 36151233; PMCID: PMC9508268. 2: Velazquez R, Meechoovet B, Ow A, Foley C, Shaw A, Smith B, Oddo S, Hulme C, Dunckley T. Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice. Mol Neurobiol. 2019 Dec;56(12):8364-8375. doi: 10.1007/s12035-019-01684-9. Epub 2019 Jun 25. PMID: 31240602.