Atropine Sulfate hydrate | CAS#5908-99-6

MedKoo Cat#: 317300 | Name: Atropine Sulfate hydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atropine sulfate is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors. This medication is used before eye examinations and to treat certain eye conditions. It belongs to a class of drugs known as anticholinergics.

Chemical Structure

Atropine Sulfate hydrate

CAS#5908-99-6 (sulfate)

Theoretical Analysis

MedKoo Cat#: 317300

Name: Atropine Sulfate hydrate

CAS#: 5908-99-6 (sulfate)

Chemical Formula: C34H50N2O11S

Exact Mass: 0.0000

Molecular Weight: 694.84

Elemental Analysis: C, 58.77; H, 7.25; N, 4.03; O, 25.33; S, 4.61

Price and Availability

Size	Price	Availability	Quantity
1g	USD 250.00	2 weeks
5g	USD 550.00	2 weeks

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Related CAS #

5908-99-6 (sulfate) 6415-90-3 (HBr) 51-55-8 (free base)

Synonym

Atropine sulphate; Sulfatropinol; Tropintran; Atropette; Corbella; Atropine Sulfate; Atropine Sulfate hydrate

IUPAC/Chemical Name

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate hemisulfate hydrate

InChi Key

JPKKQJKQTPNWTR-CHYDPLAESA-N

InChi Code

InChI=1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

SMILES Code

OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@H](OC(C(C3=CC=CC=C3)CO)=O)C2.CN4[C@H]5CC[C@@H]4C[C@H](OC(C(C6=CC=CC=C6)CO)=O)C5.O

Appearance

White solid powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 694.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Comparison of the effects of topical and systemic atropine sulfate on intraocular pressure and pupil diameter in the normal canine eye. Vet Ophthalmol. 2015 Jan;18(1):43-9. doi: 10.1111/vop.12138. Epub 2014 Jan 16. PubMed PMID: 24428364. 5: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3291-4. Chinese. PubMed PMID: 24422394. 6: Shen S, Yao J, Shi Y. Quantitative proton nuclear magnetic resonance for the structural and quantitative analysis of atropine sulfate. J Pharm Biomed Anal. 2014 Feb;89:118-21. doi: 10.1016/j.jpba.2013.10.036. Epub 2013 Nov 7. PubMed PMID: 24280740. 7: Ettehadi HA, Ghalandari R, Shafaati A, Foroutan SM. Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability. Iran J Pharm Res. 2013 Winter;12(Suppl):31-6. PubMed PMID: 24250669; PubMed Central PMCID: PMC3813366. 8: Byadagi KS, Nandibewoor ST, Chimatadar SA. Catalytic activity of ruthenium(III) on the oxidation of an anticholinergic drug-atropine sulfate monohydrate by copper(III) periodate complex in aqueous alkaline medium - decarboxylation and free radical mechanism. Acta Chim Slov. 2013;60(3):617-27. PubMed PMID: 24169716. 9: Abutarbush SM, Alfaqeeh SM, Mustafa G, Qura'n L, Al-Majali AM. Evaluation of the use of atropine sulfate, a combination of butylscopolammonium bromide and metamizole sodium, and flunixin meglumine to ameliorate clinical adverse effects of imidocarb dipropionate in horses. Am J Vet Res. 2013 Nov;74(11):1404-8. doi: 10.2460/ajvr.74.11.1404. PubMed PMID: 24168305. 10: Perkins MW, Pierre Z, Sabnekar P, Sciuto AM, Song J, Soojhawon I, Oguntayo S, Doctor BP, Nambiar MP. Aerosolized delivery of oxime MMB-4 in combination with atropine sulfate protects against soman exposure in guinea pigs. Inhal Toxicol. 2012 Aug;24(9):539-49. doi: 10.3109/08958378.2012.691912. PubMed PMID: 22860999. 11: Corcoran TE, Venkataramanan R, Hoffman RM, George MP, Petrov A, Richards T, Zhang S, Choi J, Gao YY, Oakum CD, Cook RO, Donahoe M. Systemic delivery of atropine sulfate by the MicroDose Dry-Powder Inhaler. J Aerosol Med Pulm Drug Deliv. 2013 Feb;26(1):46-55. doi: 10.1089/jamp.2011.0948. Epub 2012 Jun 12. PubMed PMID: 22691110; PubMed Central PMCID: PMC4227439. 12: Wu H, Fan Z. Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate in biological fluids. Spectrochim Acta A Mol Biomol Spectrosc. 2012 May;90:131-4. doi: 10.1016/j.saa.2012.01.041. Epub 2012 Jan 27. PubMed PMID: 22336044. 13: Perkins MW, Pierre Z, Rezk P, Song J, Marshall S, Oguntayo S, Morthole V, Sciuto AM, Doctor BP, Nambiar MP. Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs. Inhal Toxicol. 2011 Mar;23(4):182-95. doi: 10.3109/08958378.2011.554458. PubMed PMID: 21456952. 14: Survey of Survivors After Out-of-hospital Cardiac Arrest in KANTO Area, Japan (SOS-KANTO) Study Group. Atropine sulfate for patients with out-of-hospital cardiac arrest due to asystole and pulseless electrical activity. Circ J. 2011;75(3):580-8. Epub 2011 Jan 8. PubMed PMID: 21233578. 15: Rajpal S, Ali R, Bhatnagar A, Bhandari SK, Mittal G. Clinical and bioavailability studies of sublingually administered atropine sulfate. Am J Emerg Med. 2010 Feb;28(2):143-50. doi: 10.1016/j.ajem.2008.10.025. PubMed PMID: 20159382. 16: Uchida M, Yoshida K, Shimizu K. Effect of atropine sulfate on gastric emptying and gastrocecal transit time evaluated by using the [1-(13)C]acetic acid and lactose-[(13)C]ureide breath test in conscious rats. J Breath Res. 2009 Dec;3(4):047003. doi: 10.1088/1752-7155/3/4/047003. Epub 2009 Nov 27. PubMed PMID: 21386200. 17: Siegling-Vlitakis C, Martens H, Lüdtke R. In vitro examination of potentized atropine sulfate dilutions on the contractility of the isolated rat ileum. J Altern Complement Med. 2009 Oct;15(10):1121-6. doi: 10.1089/acm.2008.0614. PubMed PMID: 19824820. 18: Aghamohammadi H, Mehrabi S, Mohammad Ali Beigi F. Prevention of bradycardia by atropine sulfate during urological laparoscopic surgery: a randomized controlled trial. Urol J. 2009 Spring;6(2):92-5. PubMed PMID: 19472126. 19: Kameya H, Hokama N, Hobara N, Ohshiro S, Uno T. Effects of a dopamine receptor agonist and atropine sulfate on absorption of valproic acid in rats. Biomed Res. 2009 Apr;30(2):101-6. PubMed PMID: 19420733. 20: Shimokawa M, Matsushita S, Kanekura T. Successful treatment of multiple eccrine hidrocystoma with topical atropine sulfate ointment. J Dermatol. 2009 Feb;36(2):114-5. doi: 10.1111/j.1346-8138.2009.00602.x. PubMed PMID: 19284459.