Hymexazol | CAS#10004-44-1 | fungicide

MedKoo Cat#: 146252 | Name: Hymexazol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hymexazol is a systemic fungicide and soil disinfectant commonly used to control soil-borne fungal diseases such as damping-off, root rot, and seedling blight, especially in crops like sugar beets and rice. It is often applied as a seed treatment or soil drench. The compound works by inhibiting RNA synthesis in pathogenic fungi, disrupting their growth and reproduction. Hymexazol is valued for its rapid uptake and protective action against Pythium, Fusarium, and other harmful fungi in early plant development stages.

Chemical Structure

Hymexazol

CAS#10004-44-1

Theoretical Analysis

MedKoo Cat#: 146252

Name: Hymexazol

CAS#: 10004-44-1

Chemical Formula: C4H5NO2

Exact Mass: 99.0320

Molecular Weight: 99.09

Elemental Analysis: C, 48.49; H, 5.09; N, 14.14; O, 32.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hymexazol;

IUPAC/Chemical Name

5-methylisoxazol-3(2H)-one

InChi Key

KGVPNLBXJKTABS-UHFFFAOYSA-N

InChi Code

1S/C4H5NO2/c1-3-2-4(6)5-7-3/h2H,1H3,(H,5,6)

SMILES Code

CC1=CC(=O)NO1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 99.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang Y, Wei D, Wu X, Duan T, Xu J, Dong F, Pan X, Zheng Y. Occurrence and impact of carbendazim and hymexazol residues on yeast growth and ochratoxin A contamination during wine production. J Sci Food Agric. 2023 Oct;103(13):6280-6287. doi: 10.1002/jsfa.12699. Epub 2023 Jun 11. PMID: 37177869. 2: Nguyen LT, Hoang GL, Tran UN, Mai TV, Nguyen HD, Huynh LK. Mechanistic and Kinetic Insights into OH-Initiated Atmospheric Oxidation of Hymexazol: A Computational Study. Environ Sci Technol. 2023 Oct 10;57(40):15138-15152. doi: 10.1021/acs.est.2c03095. Epub 2023 Oct 2. PMID: 37782022. 3: Gao K, Qin Y, Wang L, Li X, Liu S, Xing R, Yu H, Chen X, Li P. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy. J Agric Food Chem. 2022 Aug 3;70(30):9520-9535. doi: 10.1021/acs.jafc.2c02507. Epub 2022 Jul 25. PMID: 35877994. 4: Zhang C, Wang W, Xue M, Liu Z, Zhang Q, Hou J, Xing M, Wang R, Liu T. The Combination of a Biocontrol Agent Trichoderma asperellum SC012 and Hymexazol Reduces the Effective Fungicide Dose to Control Fusarium Wilt in Cowpea. J Fungi (Basel). 2021 Aug 25;7(9):685. doi: 10.3390/jof7090685. PMID: 34575723; PMCID: PMC8471890. 5: Antypenko L, Meyer F, Sadyk Z, Shabelnyk K, Kovalenko S, Steffens KG, Garbe LA. Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase. J Fungi (Basel). 2023 Jan 5;9(1):79. doi: 10.3390/jof9010079. PMID: 36675900; PMCID: PMC9866229. 6: Deng H, Ma X, Wang Y, Zhou S, Li X, Li W, Liu Z. Preparation of multi- modified/carbonized/gelatinized starch and its de-risking effect on Cd(II) and hymexazol in wastewater. Int J Biol Macromol. 2024 Oct;278(Pt 2):134768. doi: 10.1016/j.ijbiomac.2024.134768. Epub 2024 Aug 14. PMID: 39151865. 7: Meyer C, Jeanbille M, Breuil MC, Bru D, Höfer K, Screpanti C, Philippot L. Dynamic response of soil microbial communities and network to hymexazol exposure. Sci Total Environ. 2024 Dec 20;957:177557. doi: 10.1016/j.scitotenv.2024.177557. Epub 2024 Nov 20. PMID: 39557169. 8: Hassanen EI, Hussien AM, Hassan NH, Ibrahim MA, Mehanna S. A Comprehensive Study on the Mechanistic Way of Hexaflumuron and Hymexazol Induced Neurobehavioral Toxicity in Rats. Neurochem Res. 2022 Oct;47(10):3051-3062. doi: 10.1007/s11064-022-03654-5. Epub 2022 Jun 30. PMID: 35773501; PMCID: PMC9470636. 9: Zhou X, Tu Y, Xiong C, Ma C, Wang Y, Liu F, Li K. Evaluating the Efficacy of Hymexazol in Controlling Globisporangium spinosum, the Newly Identified Pathogen Causing Root Rot in Houttuynia cordata. Plant Dis. 2024 Jul;108(7):2081-2089. doi: 10.1094/PDIS-10-23-2165-RE. Epub 2024 Jun 12. PMID: 38386301. 10: Hassan NH, Mehanna S, Hussien AM, Ibrahim MA, Hassanen EI. The potential mechanism underlying the hepatorenal toxicity induced by hymexazol in rats and the role of NF-κB signaling pathway. J Biochem Mol Toxicol. 2023 Apr;37(4):e23304. doi: 10.1002/jbt.23304. Epub 2023 Jan 12. PMID: 36636781. 11: Al-Balushi ZM, Agrama H, Al-Mahmooli IH, Maharachchikumbura SSN, Al-Sadi AM. Development of Resistance to Hymexazol Among Pythium Species in Cucumber Greenhouses in Oman. Plant Dis. 2018 Jan;102(1):202-208. doi: 10.1094/PDIS-11-16-1680-RE. Epub 2017 Oct 23. PMID: 30673464. 12: Fan Y, Miao W, Lai K, Huang W, Song R, Li QX. Developmental toxicity and inhibition of the fungicide hymexazol to melanin biosynthesis in zebrafish embryos. Pestic Biochem Physiol. 2018 May;147:139-144. doi: 10.1016/j.pestbp.2017.10.007. Epub 2017 Oct 21. PMID: 29933984. 13: Jiang Z, Li H, Cao X, Du P, Shao H, Jin F, Jin M, Wang J. Determination of hymexazol in 26 foods of plant origin by modified QuEChERS method and liquid chromatography tandem-mass spectrometry. Food Chem. 2017 Aug 1;228:411-419. doi: 10.1016/j.foodchem.2017.02.014. Epub 2017 Feb 8. PMID: 28317742. 14: Zheng Z, Xu M, Cheng C, Du H, Peng F, Wang X, Yang Y, Zhang H, Hou W. Antifungal and controlled release properties of hymexazol-chitosan-graphene oxide composite. Int J Biol Macromol. 2025 Mar 9;307(Pt 1):141848. doi: 10.1016/j.ijbiomac.2025.141848. Epub ahead of print. PMID: 40068744. 15: Liu Y, Zhang J, Sheng X, Li N, Ping Q. Adsorption and Release Kinetics, Equilibrium, and Thermodynamic Studies of Hymexazol onto Diatomite. ACS Omega. 2020 Nov 6;5(45):29504-29512. doi: 10.1021/acsomega.0c04449. PMID: 33225181; PMCID: PMC7675930. 16: Li F, Luo Q, Wang J, Li X, Wang F, Han Q, Huang B. Effects of root- irrigation with metalaxyl-M and hymexazol on soil physical and chemical properties, enzyme activity, and the fungal diversity, community structure and function. J Environ Sci Health B. 2024;59(12):767-777. doi: 10.1080/03601234.2024.2428911. Epub 2024 Nov 18. PMID: 39555951. 17: Sun D, Li L, Ji R, Li W, Ye H, Wu Y, Liu C. Determination of hymexazol in cucumber and soil samples by derivatization using GC-FPD. Bull Environ Contam Toxicol. 2011 Dec;87(6):653-6. doi: 10.1007/s00128-011-0421-x. Epub 2011 Sep 30. PMID: 21959994. 18: Ali-Shtayeh M, Salah AM, Jamous RM. Ecology of hymexazol-insensitive Pythium species in field soils. Mycopathologia. 2003;156(4):333-42. doi: 10.1023/b:myco.0000003561.47451.f7. PMID: 14682460. 19: Tamura Y, Takano I, Kobayashi M, Tomizawa S, Tateishi Y, Sakai N, Kamijo K, Ibe A, Nagayama T. [Determination of hymexazol in agricultural products by GC- NPD]. Shokuhin Eiseigaku Zasshi. 2008 Jun;49(3):223-7. Japanese. doi: 10.3358/shokueishi.49.223. PMID: 18633207. 20: European Food Safety Authority (EFSA); Anastassiadou M, Brancato A, Carrasco Cabrera L, Ferreira L, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Reich H, Rojas A, Sacchi A, Santos M, Stanek A, Theobald A, Vagenende B, Verani A. Review of the existing maximum residue levels for hymexazol according to Article 12 of Regulation (EC) No 396/2005. EFSA J. 2019 Nov 21;17(11):e05895. doi: 10.2903/j.efsa.2019.5895. PMID: 32626180; PMCID: PMC7008893.