MedKoo Cat#: 317351 | Name: Bromazepam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromazepam is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It has mainly an anti-anxiety agent with similar side effects to diazepam (Valium). In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam is contraindicated and should be used with caution in women who are pregnant, the elderly, patients with a history of alcohol or other substance abuse disorders and children. Bromazepam is discontinued.

Chemical Structure

Bromazepam
Bromazepam
CAS#1812-30-2

Theoretical Analysis

MedKoo Cat#: 317351

Name: Bromazepam

CAS#: 1812-30-2

Chemical Formula: C14H10BrN3O

Exact Mass: 315.0007

Molecular Weight: 316.15

Elemental Analysis: C, 53.19; H, 3.19; Br, 25.27; N, 13.29; O, 5.06.

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Bromazepam, Ro 53350, Ro-53350, Ro53350, Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze, Somalium, Lexotanil
IUPAC/Chemical Name
7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one
InChi Key
VMIYHDSEFNYJSL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)
SMILES Code
O=C1NC2=CC=C(Br)C=C2C(C3=NC=CC=C3)=NC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aprigio D, Adolfo W, Bittencourt J, Gongora M, Teixeira S, Basile LF, Budde H, Cagy M, Ribeiro P, Velasques B. Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects. Arq Neuropsiquiatr. 2015 Nov;73(11):918-23. doi: 10.1590/0004-282X20150140. PubMed PMID: 26517214. 2: Samanidou V, Kaltzi I, Kabir A, Furton KG. Simplifying sample preparation using fabric phase sorptive extraction technique for the determination of benzodiazepines in blood serum by high-performance liquid chromatography. Biomed Chromatogr. 2015 Sep 17. doi: 10.1002/bmc.3615. [Epub ahead of print] PubMed PMID: 26378746.