MedKoo Cat#: 125676 | Name: DOTA-c(RGDyK)
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DOTA-c(RGDyK) is useful ligand for making 225Ac-DOTA-c(RGDyK), which is a potential radiopharmaceutical for targeted alpha particle therapy.

Chemical Structure

DOTA-c(RGDyK)
DOTA-c(RGDyK)
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125676

Name: DOTA-c(RGDyK)

CAS#: N/A

Chemical Formula: C43H67N13O15

Exact Mass: 1005.4900

Molecular Weight: 1006.09

Elemental Analysis: C, 51.33; H, 6.71; N, 18.10; O, 23.85

Price and Availability

Size Price Availability Quantity
10mg USD 1,250.00 2 Weeks
50mg USD 2,050.00 2 Weeks
100mg USD 3,850.00 2 Weeks
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Related CAS #
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Synonym
DOTA-c(RGDyK); DOTA c(RGDyK); DOTA-c-(RGDyK)
IUPAC/Chemical Name
2,2',2''-(10-(2-((4-(11-(carboxymethyl)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)butyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
InChi Key
OJQZKJZWMRREFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C43H67N13O15/c44-43(45)47-11-3-5-29-39(68)48-22-33(58)49-32(21-35(60)61)42(71)52-31(20-27-6-8-28(57)9-7-27)41(70)51-30(40(69)50-29)4-1-2-10-46-34(59)23-53-12-14-54(24-36(62)63)16-18-56(26-38(66)67)19-17-55(15-13-53)25-37(64)65/h6-9,29-32,57H,1-5,10-26H2,(H,46,59)(H,48,68)(H,49,58)(H,50,69)(H,51,70)(H,52,71)(H,60,61)(H,62,63)(H,64,65)(H,66,67)(H4,44,45,47)
SMILES Code
O=C(NCCCCC1C(NC(CCCNC(N)=N)C(NCC(NC(CC(O)=O)C(NC(CC2=CC=C(O)C=C2)C(N1)=O)=O)=O)=O)=O)CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,006.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Pandya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ. Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization. Theranostics. 2016 Mar 1;6(5):698-709. doi: 10.7150/thno.14338. PMID: 27022417; PMCID: PMC4805664.