Synonym
Dersalazine Free Base; UR12746; UR 12746; UR-12746
IUPAC/Chemical Name
2-Hydroxy-5-((4-((1Z)-3-(4-((2-methyl-1H-imidazo(4,5-c)pyridin-1-yl)methyl)piperidin-1-yl)-3-oxo-1-phenylprop-1-enyl)phenyl)diazenyl)benzoic acid
InChi Key
AYEAMZDTWLXZIJ-RKOUKRECSA-N
InChi Code
InChI=1S/C35H32N6O4/c1-23-37-31-21-36-16-13-32(31)41(23)22-24-14-17-40(18-15-24)34(43)20-29(25-5-3-2-4-6-25)26-7-9-27(10-8-26)38-39-28-11-12-33(42)30(19-28)35(44)45/h2-13,16,19-21,24,42H,14-15,17-18,22H2,1H3,(H,44,45)/b29-20-,39-38+
SMILES Code
O=C(O)C1=CC(/N=N/C2=CC=C(/C(C3=CC=CC=C3)=C\C(N4CCC(CN5C(C)=NC6=C5C=CN=C6)CC4)=O)C=C2)=CC=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
600.68
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pontes C, Vives R, Torres F, Panés J. Safety and activity of dersalazine sodium in patients with mild-to-moderate active colitis: double-blind randomized proof of concept study. Inflamm Bowel Dis. 2014 Nov;20(11):2004-12. doi: 10.1097/MIB.0000000000000166. PMID: 25192498.
2: Camuesco D, Rodríguez-Cabezas ME, Garrido-Mesa N, Cueto-Sola M, Bailón E, Comalada M, Arribas B, Merlos M, Balsa D, Zarzuelo A, Janer G, Xaus J, Román J, Gálvez J. The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 Feb;165(3):729-40. doi: 10.1111/j.1476-5381.2011.01598.x. PMID: 21790535; PMCID: PMC3315044.
3: Román J, Planell N, Lozano JJ, Aceituno M, Esteller M, Pontes C, Balsa D, Merlos M, Panés J, Salas A. Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis. Inflamm Bowel Dis. 2013 Feb;19(2):221-9. doi: 10.1002/ibd.23020. PMID: 22605655.
4: Gálvez J, Garrido M, Rodríguez-Cabezas ME, Ramis I, de Medina FS, Merlos M, Zarzuelo A. The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. Inflamm Bowel Dis. 2003 Nov;9(6):363-71. doi: 10.1097/00054725-200311000-00004. PMID: 14671485.
