Synonym
711389-S; 711389 S; 711389S; S 1389; S-1389; S1389;
IUPAC/Chemical Name
(S)-1-(2-(1-(1H-imidazol-1-yl)vinyl)-3,6-dichlorophenoxy)-3-(isopropylamino)propan-2-ol
InChi Key
DROIRVKNZDBEFR-ZDUSSCGKSA-N
InChi Code
InChI=1S/C17H21Cl2N3O2/c1-11(2)21-8-13(23)9-24-17-15(19)5-4-14(18)16(17)12(3)22-7-6-20-10-22/h4-7,10-11,13,21,23H,3,8-9H2,1-2H3/t13-/m0/s1
SMILES Code
O[C@@H](CNC(C)C)COC1=C(Cl)C=CC(Cl)=C1C(N2C=CN=C2)=C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
370.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kotake H, Hisatome I, Hasegawa J, Yamasaki J, Kosaka T, Furuse T, Mashiba H. Inhibitory action of 711389-S on the electrical activity of rabbit sinoatrial node. Cardiovasc Res. 1987 Mar;21(3):197-201. PubMed PMID: 3652085.
2: Ninomiya M, Tani T, Ueda M. Effects of S-1389 (711389-S), a new antiarrhythmic agent, on the conduction in perfused guinea pig hearts. Jpn J Pharmacol. 1989 Dec;51(4):555-62. PubMed PMID: 2615048.
3: Iwaki K, Ishii M, Shinosaki T, Ueda M, Yonetani Y. Effect of 711389-S, a new antiarrhythmic agent, on myocardial energy metabolism in guinea-pigs and rats. J Pharm Pharmacol. 1988 Jan;40(1):10-6. PubMed PMID: 2896767.
4: Nakajima S, Ueda M. Increase of the ventricular fibrillation threshold by 711389-S, a new antiarrhythmic agent, in guinea-pigs. Jpn J Pharmacol. 1985 Aug;38(4):436-8. PubMed PMID: 3840850.
5: Kadowaki Y, Ohta T, Hotokebuchi N, Kimoto S, Haruna M, Nakao T, Ueda M, Nishi K. Actions of a newly synthesized compound (711389-S) on various types of experimentally induced arrhythmias in mammalian species in situ. Jpn J Pharmacol. 1988 Apr;46(4):359-72. PubMed PMID: 3404766.
6: Ninomiya M, Toyama J, Kodama I, Yamada K. Electrophysiological effects of 711389-S, a new antiarrhythmic agent, on guinea-pig isolated cardiac muscle. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1222-9. PubMed PMID: 6084783.
7: Muramatsu I, Noda M, Nishio M, Fujiwara M. Mechanism of sodium channel block in crayfish giant axons by 711389-S, a new antiarrhythmic drug. J Pharmacol Exp Ther. 1987 Jul;242(1):269-76. PubMed PMID: 2441025.
8: Hisatome I, Matsuoka S, Miyamoto J, Sawaguchi M, Omodani H, Osaki S, Kotake H, Mashiba H, Sato R. Blocking effect of 1389-S on the sodium current in isolated guinea-pig ventricular myocytes. Eur J Pharmacol. 1990 Apr 25;179(3):447-51. PubMed PMID: 2163858.
