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MedKoo Cat#: 146213 | Name: Trendione

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trendione, also known as estra-4,9,11-triene-3,17-dione, is a synthetic anabolic steroid and a metabolite of the prohormone trenbolone. It serves as a precursor that is converted in the body to trenbolone, a powerful anabolic-androgenic steroid known for promoting muscle growth and strength. Trendione itself exhibits weak androgenic activity but becomes highly active after enzymatic conversion. Its applications are primarily in bodybuilding and performance enhancement, though its use is banned in many sports and raises health concerns due to potential hormonal side effects.

Chemical Structure

Trendione
Trendione
CAS#4642-95-9

Theoretical Analysis

MedKoo Cat#: 146213

Name: Trendione

CAS#: 4642-95-9

Chemical Formula: C17H21NO3

Exact Mass: 287.1521

Molecular Weight: 287.36

Elemental Analysis: C, 71.06; H, 7.37; N, 4.87; O, 16.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Trendione;
IUPAC/Chemical Name
((1R,7aR)-hexahydro-1H-pyrrolizin-1-yl)methyl (E)-3-(4-hydroxyphenyl)acrylate
InChi Key
KBSXJBBFQODDTQ-RYRKJORJSA-N
InChi Code
1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-16H,2-7H2,1H3/t15-,16+,18+/m1/s1
SMILES Code
C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 287.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robinson JA, Ma Q, Staveley JP, Smolenski WJ. Sorption and desorption of 17α-trenbolone and trendione on five soils. Environ Toxicol Chem. 2017 Mar;36(3):613-620. doi: 10.1002/etc.3711. PMID: 27958649. 2: Robinson JA, Ma Q, Staveley JP, Smolenski WJ, Ericson J. Degradation and transformation of 17α-trenbolone in aerobic water-sediment systems. Environ Toxicol Chem. 2017 Mar;36(3):630-635. doi: 10.1002/etc.3381. Epub 2016 Jun 13. PMID: 26800846. 3: Khan B, Lee LS, Sassman SA. Degradation of synthetic androgens 17alpha- and 17beta-trenbolone and trendione in agricultural soils. Environ Sci Technol. 2008 May 15;42(10):3570-4. doi: 10.1021/es702690p. PMID: 18546691. 4: Khan B, Lee LS. Soil temperature and moisture effects on the persistence of synthetic androgen 17alpha-trenbolone, 17beta-trenbolone and trendione. Chemosphere. 2010 May;79(8):873-9. doi: 10.1016/j.chemosphere.2010.02.036. Epub 2010 Mar 15. PMID: 20231030. 5: Blackwell BR, Cai Q, Smith PN, Cobb GP. Liquid chromatography-tandem mass spectrometry analysis of 17α-trenbolone, 17β-trenbolone and trendione in airborne particulate matter. Talanta. 2011 Sep 15;85(3):1317-23. doi: 10.1016/j.talanta.2011.06.011. Epub 2011 Jun 14. PMID: 21807189. 6: Forsgren KL, Qu S, Lavado R, Cwiertny D, Schlenk D. Trenbolone acetate metabolites promote ovarian growth and development in adult Japanese medaka (Oryzias latipes). Gen Comp Endocrinol. 2014 Jun 1;202:1-7. doi: 10.1016/j.ygcen.2014.04.011. Epub 2014 Apr 26. PMID: 24780119. 7: Blackwell BR, Karnjanapiboonwong A, Anderson TA, Smith PN. Uptake of 17β-trenbolone and subsequent metabolite trendione by the pinto bean plant (Phaseolus vulgaris). Ecotoxicol Environ Saf. 2012 Nov;85:110-4. doi: 10.1016/j.ecoenv.2012.08.006. Epub 2012 Sep 2. PMID: 22951338. 8: Khan B, Qiao X, Lee LS. Stereoselective sorption by agricultural soils and liquid-liquid partitioning of trenbolone (17alpha and 17beta) and trendione. Environ Sci Technol. 2009 Dec 1;43(23):8827-33. doi: 10.1021/es902112v. PMID: 19943653. 9: Challis JK, Sura S, Cantin J, Curtis AW, Shade KM, McAllister TA, Jones PD, Giesy JP, Larney FJ. Ractopamine and Other Growth-Promoting Compounds in Beef Cattle Operations: Fate and Transport in Feedlot Pens and Adjacent Environments. Environ Sci Technol. 2021 Feb 2;55(3):1730-1739. doi: 10.1021/acs.est.0c06450. Epub 2021 Jan 15. PMID: 33450151. 10: Cole EA, McBride SA, Kimbrough KC, Lee J, Marchand EA, Cwiertny DM, Kolodziej EP. Rates and product identification for trenbolone acetate metabolite biotransformation under aerobic conditions. Environ Toxicol Chem. 2015 Jul;34(7):1472-84. doi: 10.1002/etc.2962. Epub 2015 May 14. PMID: 25727029. 11: Jones GD, Benchetler PV, Tate KW, Kolodziej EP. Mass balance approaches to characterizing the leaching potential of trenbolone acetate metabolites in agro- ecosystems. Environ Sci Technol. 2014 Apr 1;48(7):3715-23. doi: 10.1021/es405701f. Epub 2014 Mar 19. PMID: 24597797. 12: Sangster JL, Zhang Y, Hernandez R, Garcia YA, Sivils JC, Cox MB, Snow DD, Kolok AS, Bartelt-Hunt SL. Bioavailability and fate of sediment-associated trenbolone and estradiol in aquatic systems. Sci Total Environ. 2014 Oct 15;496:576-584. doi: 10.1016/j.scitotenv.2014.07.040. Epub 2014 Aug 8. PMID: 25108798. 13: Zhang Y, Snow DD, Bartelt-Hunt SL. Stereoselective Degradation of Estradiol and Trenbolone Isomers in Alluvial Sediment. Environ Sci Technol. 2016 Dec 20;50(24):13256-13264. doi: 10.1021/acs.est.6b02171. Epub 2016 Nov 30. PMID: 27993082. 14: Gall HE, Sassman SA, Lee LS, Jafvert CT. Hormone discharges from a midwest tile-drained agroecosystem receiving animal wastes. Environ Sci Technol. 2011 Oct 15;45(20):8755-64. doi: 10.1021/es2011435. Epub 2011 Sep 19. PMID: 21877728. 15: Qiao X, Carmosini N, Li F, Lee LS. Probing the primary mechanisms affecting the environmental distribution of estrogen and androgen isomers. Environ Sci Technol. 2011 May 1;45(9):3989-95. doi: 10.1021/es200073h. Epub 2011 Apr 5. PMID: 21466196. 16: Yang X , Zhao H , Cwiertny DM , Kolodziej EP . Sorption and transport of trenbolone and altrenogest photoproducts in soil-water systems. Environ Sci Process Impacts. 2019 Oct 16;21(10):1650-1663. doi: 10.1039/c9em00305c. PMID: 31490490. 17: Card ML, Chin YP, Lee LS, Khan B. Prediction and experimental evaluation of soil sorption by natural hormones and hormone mimics. J Agric Food Chem. 2012 Feb 15;60(6):1480-7. doi: 10.1021/jf203093d. Epub 2012 Jan 31. PMID: 22224428. 18: Jones GD, Benchetler PV, Tate KW, Kolodziej EP. Surface and subsurface attenuation of trenbolone acetate metabolites and manure-derived constituents in irrigation runoff on agro-ecosystems. Environ Sci Process Impacts. 2014 Nov;16(11):2507-16. doi: 10.1039/c4em00385c. PMID: 25308255. 19: Zhang Y, Sangster JL, Gauza L, Bartelt-Hunt SL. Impact of sediment particle size on biotransformation of 17β-estradiol and 17β-trenbolone. Sci Total Environ. 2016 Dec 1;572:207-215. doi: 10.1016/j.scitotenv.2016.08.004. Epub 2016 Aug 4. PMID: 27498382. 20: Spranger B, Metzler M. Disposition of 17 beta-trenbolone in humans. J Chromatogr. 1991 Apr 5;564(2):485-92. PMID: 1874853.