MedKoo Cat#: 532557 | Name: Ro26-4550

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro26-4550 is a competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Ro26-4550 appears to compete with IL-2Rα for its binding site on IL-2.

Chemical Structure

Ro26-4550
Ro26-4550
CAS#193744-04-6

Theoretical Analysis

MedKoo Cat#: 532557

Name: Ro26-4550

CAS#: 193744-04-6

Chemical Formula: C26H30N4O3

Exact Mass: 446.2318

Molecular Weight: 446.55

Elemental Analysis: C, 69.93; H, 6.77; N, 12.55; O, 10.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Ro26-4550; Ro 26-4550; Ro-26-4550.
IUPAC/Chemical Name
methyl (2S)-2-{2-[(3R)-1-methanehydrazonoylpiperidin-3-yl]acetamido}-3-[4-(2-phenylethynyl)phenyl]propanoate
InChi Key
YQDXLNDLKSCQKX-VNLZXBPESA-N
InChi Code
InChI=1S/C26H30N4O3/c1-33-26(32)24(29-25(31)17-23-8-5-15-30(18-23)19-28-27)16-22-13-11-21(12-14-22)10-9-20-6-3-2-4-7-20/h2-4,6-7,11-14,19,23-24H,5,8,15-18,27H2,1H3,(H,29,31)/b28-19+/t23-,24+/m1/s1
SMILES Code
O=C(OC)[C@@H](NC(C[C@@H]1CN(/C=N/N)CCC1)=O)CC2=CC=C(C#CC3=CC=CC=C3)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim D, Ryu HG, Ahn KH. Recent development of two-photon fluorescent probes for bioimaging. Org Biomol Chem. 2014 Jul 14;12(26):4550-66. doi: 10.1039/c4ob00431k. Review. PubMed PMID: 24838728.