MedKoo Cat#: 406466 | Name: FTI-249

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100–200 nM).

Chemical Structure

FTI-249
FTI-249
CAS#161721-65-9

Theoretical Analysis

MedKoo Cat#: 406466

Name: FTI-249

CAS#: 161721-65-9

Chemical Formula: C15H23N3O3S2

Exact Mass: 357.1181

Molecular Weight: 357.49

Elemental Analysis: C, 50.40; H, 6.48; N, 11.75; O, 13.43; S, 17.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FTI249; FTI 249; FTI-249.
IUPAC/Chemical Name
(S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid.
InChi Key
IPZVKZRBOSROBN-YPMHNXCESA-N
InChi Code
InChI=1S/C15H23N3O3S2/c1-23-7-6-13(15(20)21)18-14(19)10-2-4-12(5-3-10)17-8-11(16)9-22/h2-5,11,13,17,22H,6-9,16H2,1H3,(H,18,19)(H,20,21)/t11-,13+/m1/s1
SMILES Code
CSCC[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1)=O
Appearance
white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
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Preparing Stock Solutions

The following data is based on the product molecular weight 357.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Machida S, Tsubamoto M, Kato N, Harada K, Ohkanda J. Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors. Bioorg Med Chem. 2013 Jul 15;21(14):4004-10. doi: 10.1016/j.bmc.2012.09.061. Epub 2012 Oct 11. PubMed PMID: 23107667.