MedKoo Cat#: 465554 | Name: FTI-2628

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FTI-2628 is a novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia.

Chemical Structure

FTI-2628
FTI-2628
CAS#655234-81-4

Theoretical Analysis

MedKoo Cat#: 465554

Name: FTI-2628

CAS#: 655234-81-4

Chemical Formula: C31H34N4O3S

Exact Mass: 542.2352

Molecular Weight: 542.70

Elemental Analysis: C, 68.61; H, 6.32; N, 10.32; O, 8.84; S, 5.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FTI-2628; FTI2628; FTI 2628;
IUPAC/Chemical Name
benzyl (5-((((1H-imidazol-5-yl)methyl)amino)methyl)-2'-methyl-[1,1'-biphenyl]-2-carbonyl)-D-methioninate
InChi Key
UIOVGRXEBWMUQT-GDLZYMKVSA-N
InChi Code
InChI=1S/C31H34N4O3S/c1-22-8-6-7-11-26(22)28-16-24(17-32-18-25-19-33-21-34-25)12-13-27(28)30(36)35-29(14-15-39-2)31(37)38-20-23-9-4-3-5-10-23/h3-13,16,19,21,29,32H,14-15,17-18,20H2,1-2H3,(H,33,34)(H,35,36)/t29-/m1/s1
SMILES Code
O=C([C@H](NC(C1=C(C2=CC=CC=C2C)C=C(CNCC3=CN=CN3)C=C1)=O)CCSC)OCC4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 542.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Matti A, Kyathanahalli C, Kowluru A. Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets. 2012 Jan-Feb;4(1):74-7. doi: 10.4161/isl.19121. Epub 2012 Jan 1. PMID: 22504835; PMCID: PMC3365803. 2: Kyathanahalli CN, Kowluru A. A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂. Biochem Pharmacol. 2011 May 15;81(10):1237-47. doi: 10.1016/j.bcp.2011.03.002. Epub 2011 Mar 23. PMID: 21406184; PMCID: PMC3084372. 3: Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr;59(4):967-77. doi: 10.2337/db09-1334. Epub 2010 Jan 13. PMID: 20071600; PMCID: PMC2844844.