MedKoo Cat#: 575707 | Name: FTC-146

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FTC-146 is a sigma-1 receptor ligand.

Chemical Structure

FTC-146
FTC-146
CAS#1350296-21-7

Theoretical Analysis

MedKoo Cat#: 575707

Name: FTC-146

CAS#: 1350296-21-7

Chemical Formula: C18H25FN2OS

Exact Mass: 336.1672

Molecular Weight: 336.47

Elemental Analysis: C, 64.25; H, 7.49; F, 5.65; N, 8.33; O, 4.75; S, 9.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FTC-146; FTC 146; FTC146
IUPAC/Chemical Name
2(3H)-Benzothiazolone, 6-(3-fluoropropyl)-3-(2-(hexahydro-1H-azepin-1-yl)ethyl)-
InChi Key
DNGYIBDXSUNKMV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H25FN2OS/c19-9-5-6-15-7-8-16-17(14-15)23-18(22)21(16)13-12-20-10-3-1-2-4-11-20/h7-8,14H,1-6,9-13H2
SMILES Code
FCCCc1ccc2N(CCN3CCCCCC3)C(=O)Sc2c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bhyrapuneni G, Thentu JB, Mohammed AR, Aleti RR, Padala NP, Ajjala DR, Nirogi R. Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer. J Recept Signal Transduct Res. 2018 Aug;38(4):290-298. doi: 10.1080/10799893.2018.1478855. Epub 2018 Jun 18. PMID: 29912606. 2. van Waarde A, Rybczynska AA, Ramakrishnan NK, Ishiwata K, Elsinga PH, Dierckx RA. Potential applications for sigma receptor ligands in cancer diagnosis and therapy. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2703-14. doi: 10.1016/j.bbamem.2014.08.022. Epub 2014 Aug 27. PMID: 25173780.