A4B17 | CAS#unknown | AR inhibitor

MedKoo Cat#: 465867 | Name: A4B17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A4B17 is a novel androgen receptor (AR) inhibitor, inhibiting BAG1L–AR NTD interaction, attenuating BAG1L-mediated AR NTD activity, downregulating AR target gene expression, and inhibiting proliferation of AR-positive prostate cancer cells.

Chemical Structure

A4B17

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465867

Name: A4B17

CAS#: unknown

Chemical Formula: C14H7F4NS

Exact Mass: 297.0235

Molecular Weight: 297.27

Elemental Analysis: C, 56.57; H, 2.37; F, 25.56; N, 4.71; S, 10.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

A4B17; A4 B17; A4-B17;

IUPAC/Chemical Name

2-(4-fluorophenyl)-5-(trifluoromethyl)benzo[d]thiazole

InChi Key

HVPGYAGVCOFPJH-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H7F4NS/c15-10-4-1-8(2-5-10)13-19-11-7-9(14(16,17)18)3-6-12(11)20-13/h1-7H

SMILES Code

FC(C1=CC=C(SC(C2=CC=C(F)C=C2)=N3)C3=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 297.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kuznik NC, Solozobova V, Jung N, Gräßle S, Lei Q, Lewandowski EM, Munuganti R, Zoubeidi A, Chen Y, Bräse S, Cato ACB. Development of a Benzothiazole Scaffold-Based Androgen Receptor N-Terminal Inhibitor for Treating Androgen- Responsive Prostate Cancer. ACS Chem Biol. 2021 Nov 19;16(11):2103-2108. doi: 10.1021/acschembio.1c00390. Epub 2021 Sep 10. PMID: 34506104. 2: Tian J, Zhu L, Wang W, Zhang L, Li Z, Zhao Q, Xing K, Feng Z, Peng X. Genomic Analysis of Microbulbifer sp. Strain A4B-17 and the Characterization of Its Metabolic Pathways for 4-Hydroxybenzoic Acid Synthesis. Front Microbiol. 2018 Dec 18;9:3115. doi: 10.3389/fmicb.2018.03115. PMID: 30619190; PMCID: PMC6305291. 3: Peng X, Adachi K, Chen C, Kasai H, Kanoh K, Shizuri Y, Misawa N. Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabens. Appl Environ Microbiol. 2006 Aug;72(8):5556-61. doi: 10.1128/AEM.00494-06. PMID: 16885309; PMCID: PMC1538717.