MedKoo Cat#: 145587 | Name: Koenine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Koenine is a carbazole alkaloid. Koenine may have the potential to restrict SARS-CoV-2 replication by inactivating the Mpro catalytic activity.

Chemical Structure

Koenine
Koenine
CAS#28200-63-7

Theoretical Analysis

MedKoo Cat#: 145587

Name: Koenine

CAS#: 28200-63-7

Chemical Formula: C18H17NO2

Exact Mass: 279.1300

Molecular Weight: 279.34

Elemental Analysis: C, 77.40; H, 6.13; N, 5.01; O, 11.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Koenine; Kenine;
IUPAC/Chemical Name
3,3,5-trimethyl-3,11-dihydropyrano[3,2-a]carbazol-8-ol
InChi Key
VISKLVOLGCYFCW-UHFFFAOYSA-N
InChi Code
1S/C18H17NO2/c1-10-8-14-13-9-11(20)4-5-15(13)19-16(14)12-6-7-18(2,3)21-17(10)12/h4-9,19-20H,1-3H3
SMILES Code
CC1=C2OC(C)(C)C=CC2=C3NC4=CC=C(O)C=C4C3=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 279.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wadanambi PM, Jayathilaka N, Seneviratne KN. A Computational Study of Carbazole Alkaloids from Murraya koenigii as Potential SARS-CoV-2 Main Protease Inhibitors. Appl Biochem Biotechnol. 2023 Jan;195(1):573-596. doi: 10.1007/s12010-022-04138-6. Epub 2022 Sep 15. PMID: 36107386; PMCID: PMC9474281. 2: Joshi T, Jain T, Mahar R, Singh SK, Srivastava P, Shukla SK, Mishra DK, Bhatta RS, Banerjee D, Kanojiya S. Pyranocarbazoles from Murraya koenigii (L.) Spreng. as antimicrobial agents. Nat Prod Res. 2018 Feb;32(4):430-434. doi: 10.1080/14786419.2017.1308363. Epub 2017 Apr 3. PMID: 28368664. 3: Mandal S, Nayak A, Kar M, Banerjee SK, Das A, Upadhyay SN, Singh RK, Banerji A, Banerji J. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia. 2010 Jan;81(1):72-4. doi: 10.1016/j.fitote.2009.08.016. Epub 2009 Aug 18. PMID: 19695314. 4: Nandan S, Singh SK, Singh P, Bajpai V, Mishra AK, Joshi T, Mahar R, Shukla SK, Mishra DK, Kanojiya S. Quantitative Analysis of Bioactive Carbazole Alkaloids in Murraya koenigii (L.) from Six Different Climatic Zones of India Using UPLC/MS/MS and Their Principal Component Analysis. Chem Biodivers. 2021 Dec;18(12):e2100557. doi: 10.1002/cbdv.202100557. Epub 2021 Oct 27. PMID: 34643999. 5: Chatterjee D, Narzish F, Borade P, Singh IP. Simultaneous quantitation of nine carbazole alkaloids from Murraya koenigii (L.) Spreng by 1H qNMR spectroscopy. Nat Prod Res. 2024 Sep;38(18):3173-3181. doi: 10.1080/14786419.2023.2219819. Epub 2023 Jun 16. PMID: 37322993. 6: Xie FZ, Ming DS, Chen RY, Yu DQ. [Studies on the chemical constituents of Murraya kwangsiensis]. Yao Xue Xue Bao. 2000 Nov;35(11):826-8. Chinese. PMID: 11218858. 7: Sadwal S, Bharati S, Dar ZA, Kaur S. Chemopreventive potential of hydroethanolic Murraya koenigii leaves extract against DMBA induced breast carcinogenesis: In-silico and in-vivo study. J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117124. doi: 10.1016/j.jep.2023.117124. Epub 2023 Sep 8. PMID: 37678421.